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Avastin

Anti-VEGF Antibody (Bevacizumab Avastin Lucentis )... [Pg.86]

Bevacizumab (Avastin) Monoclonal antibody against ligand VEGFR Cancer Clinic... [Pg.1011]

Bevacizumab (Avastin ) Roche mAb VEGFR Metastatic colorectal cancer... [Pg.1193]

Bevacizumab (Avastin) Humanized antibody, lgG1 VEGF Inhibition of ligand binding CRC NSCLC... [Pg.1255]

Antibodies Avastin, Bexxar, Erbitux, Herceptin, Humaspect, Humira, Mabcampath/Campath-Hl, Mabthera/ Rituxan, Mylotarg, Neutrospec, Oncoscint, Orthoclone OKT-3, Prostascint, Raptiva, Remicade, Simulect, Synagis, Xolair, Zenapax, Zevalin... [Pg.32]

Avastin (humanized monoclonal raised against vascular endothelial growth factor). Genentech USA) Roche (EU) Carcinoma of the colon or rectum... [Pg.381]

Avastin (tradename, also known as bevacizumab) is a 149 kDa recombinant humanized monoclonal IgGl antibody first approved for medical use in the USA in 2004, and subsequently in the EU in 2005. It is indicated for first-line treatment of patients with metastatic colorectal cancer, in combination with specified (5-fluorouricil-based) small molecule chemotherapeutic drugs. [Pg.394]

Serious, sometimes fatal, side effects reported included gastrointestinal perforation, wound healing complications and haemorrhage, and the product should not be administered for at least 28 days following major surgery. Avastin was developed by Genentech. [Pg.394]

Bevacrzumab (Avastin) Monoclonal antibody to VEGF Colorectal Randomized Phase III... [Pg.447]

The three monoclonal antibodies approved, noted in Table 23.1, in the last 7 years for treatment of patients with cancer include Alemtuzumab (Campath M) (Genzyme Corporation, Cambridge, MA, U.S.A.), Cetuzimab (Erbitux ) (ImClone Corporation, Branchburg, NJ, U.S.A.), and bevacizumab (Avastin ) (Genentech, South San Francisco, CA, U.S.A.). [Pg.449]

The clinical trial with Avastin against patients renal cell carcinoma. [Pg.450]

In summary, these three approvals with the noncytotoxic monoclonal antibodies demonstrated activity based on survival (Avastin), TIP in an enriched population (Avastin in renal cell cancer), a pure response with endpoint (Campath), and a clever response rate to a combination vs. a reference point response rate with that new agent alone (Cetuximab). [Pg.451]

Avastin Bevacizumab Genentech Anti-VEGF Breast cancer 2004... [Pg.580]

Cancer Antibodies Metastatic cancer, lymphoma Herceptin, Avastin, Rituxan, Erbitux, Procrit, Gleevec, Sutent... [Pg.96]

Bevacizumab Avastin Humanized IgGl anti-VEGE Metastatic colorectal cancer 2004 United States... [Pg.114]

Source Food and Drug Administration. Avastin. http //www.fda.gov/medwatch/ SAFETY/2005/Jan PI/Avastin PI.pdf [accessed September 17,2007]. [Pg.121]

What is the mechanism of action for drugs that target growth factors Describe the mechanism of action for some of the latest drugs, such as Avastin. [Pg.133]

Section 4.4.2 shows the actions for EPO, CSFs, and VEGFs. The antiangiogenesis mechanism of Avastin is explained in Exhibit 4.12. [Pg.133]

Avastin Avastin is used for the treatment of colorectal cancer. It is supplied in 100 and 400 mg dosages. The 100 mg formulation consists of 240 mg a,a-trehalose dihydrate, 23.2 mg sodium phosphate (monobasic, monohydrate), 4.8mg sodium phosphate (dibasic, anhydrous), 1.6mg polysorbate 20 and water-for-injection. [Pg.166]

Finally, bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody has also been approved for treatment of colorectal and breast cancer. There are several... [Pg.349]

Both normal cells and tumor cells require blood circulation to provide the oxygen and the nourishment they need to survive. Bevacizumab (Avastin ) is used to treat advanced forms of cancer of the digestive system it is a reengineered mouse monoclonal antibody that binds to a growth factor receptor required for the development of blood circulation around a tumor. [Pg.81]

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Avastin injection

Avastin treatment)

Avastin vascular endothelial growth factor

Avastin, bevacizumab

Humanized monoclonal antibodies Avastin

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