Growth factors targets

Rini, B.I. and E.J. Small. 2005. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. ]. Clin. 

FI. Fairbrother, W. J., Christinger, H. W., Cochran, A. G., et al.. Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site. Biochemistry 37, 17754-17764 (1998). 

Nimni, M.E., Polypeptide growth factors targeted delivery systems. Biomaterials, 18,1201,1997. 

Growth Factors Targeted Cell Type Growth Factor Delivery Material ECM Synthesis Cell Proliferation Reference(s)... 

Jiang and co-workers also showed that the HA-PEI/siRNA complex accumulated mainly in tissues with high levels of HA receptors such as liver, kidney and tumour. Furthermore, they also showed that the intratumoural injection of anti-vascular endothelial growth factor targeted siRNA/HA-PEI complex resulted in effective inhibition of tumour growth by the GD44-mediated endocytosis to tumour cells in C57BL/6 mice [21]. 

BDNF (brain-derived neurotrophic factor) is a neuro-trophin, i.e. a target-derived growth factor, which is expressed in the brain predominantly in the hippocampus. It acts through its tyrosine kinase receptor, trkB,... 

The epidermal growth factor receptor 2 (HER-2) is a protein found on the surface of cells. Heterodimerization of HER-2 activates the enzyme tyrosine kinase, triggering reactions that cause the cells to grow and multiply. HER-2 is found at abnormally high levels on the surface of many types of cancer cells, which may divide excessively. Antibodies targeting HER-2 (e.g., trastuzumab) are used as antineoplastic agents. 

Transforming Growth Factor-Beta. Table 1 Agents that target the TGF-(3 signaling pathway... 

Wajant H, Gerspach J, Pfizenmaier K (2005) Tumor therapeutics by design targeting and activation of death receptors. Cytokine Growth Factor Rev 16 55-76... 

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