Autoradiography functional receptor

Sovago J, Dupuis DS, Gulyas B, Hall H. 2001. An overview on functional receptor autoradiography using [ SjGTPyS. Brain Res Rev 38 149-164. 

The adult brain is endowed with nuclear as well as cytosolic and membrane T3 receptors that have been visualized by autoradiography and studied biochemically [30-33]. Both neurons and neuropil are labeled by [ 1251]T3, and the labeling is selective across brain regions. Functionally, one of the most prominent features of neural action of thyroid hormone in adulthood is subsensitivity to norepinephrine as a result of a hypothyroid state [27], These changes may be reflections of loss of dendritic spines in at least some neurons of the adultbrain. Clinically, thyroid hormone deficiency increases the probability of depressive illness, whereas thyroid excess increases the probability of mania (Ch. 52) in susceptible individuals [27],... 

Dumont, Y., Chabot, J. G., and Quirion, R. (2004). Receptor autoradiography as mean to explore the possible functional relevance of neuropeptides Focus on new agonists and antagonists to study natriuretic peptides, neuropeptide Y and calcitonin gene-related peptides. Peptides 25, 365-391. 

Endogenous opioids and their multiple receptors continue as the focus of vigorous research. The proceedings of the 1983 International Narcotic Research Conference were published, and reviews were recently provided on opioid peptides,opioid receptors and their functional roles,pharmacology and therapeutic implications of enkephalins and endorphins, " cardiovascular effects of endogenous opioids, opioids and the adrenal-pituitary axis, opioids and the hippocampus, substance P in nociception, potential therapeutic roles for opioid antagonists, roles of opioid peptides in appetite control,and autoradiography of opioid receptors. 

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