Autonomic nervous system functions

In addition, the temperature, pulse, and respiratory rates for 10 infants were reviewed for evidence of drug effects on autonomic nervous system function. However, no abnormal patterns were noted during the course of hospitalization. 

Gennart J-P, Bernard A, Lauwerys R. 1992a. Assessment of thyroid, testes, kidney and autonomic nervous system function in lead-exposed workers. Int Arch Occup Environ Health 64 49-57. 

Explain how various regions of the central nervous system regulate autonomic nervous system function... 

Bensafi, M., Brown, W. M., Khan, R., Levenson, B. and Sobel, N. (2004) Sniffing human sex-steroid derived compounds modulates mood, memory and autonomic nervous system function in specific behavioral contexts. Behav. Brain Res. 152, 11-22. 

Nishikino, M., Matsunaga, T., Yasuda, K., et al. (2006) Genetic variation in the renin-angiotensin system and autonomic nervous system function in young healthy lapanese subjects. J. Clin. Endocrinol. Metab. 91, 4676 681. 

For pharmacologic research, - and K2-adrenoceptor antagonist drugs have been very useful in the experimental exploration of autonomic nervous system function. In clinical therapeutics, nonselective antagonists are used in the treatment of pheochromocytoma (tumors that secrete catecholamines), and -selective antagonists are used in primary hypertension and... 

Midodrine is a prodrug that is enzymatically hydrolyzed to desglymidodrine, an receptor-selective agonist. The peak concentration of desglymidodrine is achieved about 1 hour after midodrine is administered. The primary indication for midodrine is the treatment of postural hypotension, typically due to impaired autonomic nervous system function. While the drug has efficacy in diminishing the fall of blood pressure when the patient is standing, it may cause hypertension when the subject is supine. 

In most cases, elevated blood pressure is associated with an overall increase in resistance to flow of blood through arterioles, while cardiac output is usually normal. Meticulous investigation of autonomic nervous system function, baroreceptor reflexes, the renin-angiotensin-aldosterone system, and the kidney has failed to identify a primary abnormality as the cause of increased peripheral vascular resistance in essential hypertension. 

Effects of the test substance on the autonomic nervous system should be assessed. For example, binding to receptors relevant for the autonomic nervous system, functional responses to agonists or antagonists in vivo or in vitro, direct stimulation of autonomic nerves and measurement of cardiovascular responses, baroreflex testing, and heart rate variability can be used. 

The coimnittee concludes that the evidence is sufficient to infer causal relationships between BLLs under 40 pg/dL and adverse effects on nervous system function (see Table 4-1). Effects on both the central and peripheral nervous systems have been observed, including effects on cognitive fmction, peripheral nerve function, visual and auditory function, posture and balance, and autonomic nervous system function. 

Eustatia-Rutten CF, Corssmit EP, Heemstra KA, Smit JW, Schoemaker RC, Romijn JA, Burggraaf J. Autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring euthyroidism. J Clin Endocrinol Metab 2008 93(7) 2835 1. 

Low. P. (1993) Autonomic nervous system function. Journal of Clinical Neurr hysiolr y 10 14-27. 

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