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Automated parallel synthesis

These conceptual goals are attained by several combinatorial methods and tools. Characteristic for combinatorial chemistry is the synthesis on solid support or by polymer-supported synthesis, allowing for much higher efficiency in library production. Synthesis can be conducted either in automated parallel synthesis or by split-and-recombine synthesis. Centerpieces of combinatorial methods further include specific analytical methods for combinatorial... [Pg.381]

ChemOvation Ltd., founded in 1998, focuses on providing an integrated drug discovery support service via collaborative programs, and the manufacture of innovative compound libraries. Apart from that, their range of services includes chemistry development, automated parallel synthesis, scale-up, process development, and screening. [Pg.262]

Kirschning A, Monenschein H, Wittenberg R (2001) Functionalized polymers - emerging versatile tools for solution-phase chemistry and automated parallel synthesis. Angew Chem Int Ed 40 650-679... [Pg.182]

Schmatloch S, Van den Berg AMJ, Fijten MMW, Schubert US (2004) Automated parallel synthesis of metaUo-supramolecular polymers. Polym Mater Sci Eng 90 645-646... [Pg.14]

Keywords Automated parallel synthesis Block copolymers experimentation Polymer libraries Random copolymers... [Pg.17]

Chapon P, Mignaud C, Lizarraga G et al. (2003) Automated parallel synthesis of MADIX (co)polymers. Macromol Rapid Commun 24 87-91... [Pg.59]

Amines are both valuable synthetic intermediates and interesting target molecules. A number of solid-phase syntheses have been developed, most of which are also suitable for the automated, parallel synthesis of this class of compound. [Pg.263]

In summary, the polymer-bound oxoammonium reagent was highly efficient in polymer-supported oxidations of various alcohols and was capable of cleanly converting chemically diverse compound collections. No overoxidation to carboxylic acids was observed. It is obvious that this reagent shall be of great value in polymer-supported transformations in solution, in automated parallel synthesis operations, and in flow-through reactors in up-scaled production processes. [Pg.374]

Experiments were performed on an automated parallel synthesis workstation coupled with a personal computer supplied with software enabling the workstation to be programmed. Samples were prepared in a rack containing a 6x4 array of glass tubes. Catalytic activities were measured by means of gas chromatography. The reported activities are the averages of the results from different experiments. [Pg.214]

From the synthetic point of view, either traditional, i.e. stepwise, syntheses or by means of automated parallel synthesis as in the case of combinatorial chemistry pose the challenge of rapidly identifying most optimal representatives of the mer-ocyanines 52-55. However, based on retrosynthetic analysis (Scheme 5.10), Wurthner and coworkers [60, 63] suggested an elegant concept based on a three-component synthesis of alkenylidene-2,6-dioxo-l,2,5,6-tetrahydropyridine-3-carbonitrile merocyanines 52-55. [Pg.200]

Weller HN, Young MG, Michalczyk SJ, Reitnauer GH, Cooley RS, Rahn PC, Loyd DJ, Fiore D, Fischman SJ, High throughput analysis and purification in support of automated parallel synthesis, Molec. Diversity., 3 61-70, 1997. [Pg.268]

Mjalli AMM, Application of automated parallel synthesis, In Czarnik AW, DeWitt SH, eds., A Practical Guide to Combinatorial Chemistry, Washington, DC, American Chemical Society, pp. 327-354, 1997. [Pg.343]

Antonenko VV, Manual and automated parallel synthesis its development and application for drug discovery at Affymax-GlaxoWellcome, Presented at the First European Conference on Combinatorial Technologies, ComTech97, Freiburg, Germany, February 20-21, 1997. [Pg.343]

Antonenko VV, Manual and automated parallel synthesis of individual compounds. Presented at Strategic Research Institute s Symposium, Solid and Solution Phase Combinatorial Synthesis, New Orleans, LA, April 28-29, 1997. [Pg.343]

Automated Parallel Synthesis A Library of Tricyclic Compounds from the Tsuge Reaction... [Pg.240]

Automated Parallel Synthesis High-Throughput Parallel Optimization of SP Reaction Conditions... [Pg.243]

Powers DG, Casebier DS, Fokas D, Ryan WJ, Troth JR, Coffen DL (1998) Automated parallel synthesis of chalcone-based screening libraries. Tetrahedron 54 4085-4096... [Pg.90]

Key Words Automation parallel synthesis solid phase synthesis manual synthesizer centrifugation review. [Pg.167]

H. Tanaka, N. Matoba, H. Tsukamoto, H. Takimoto, H. Yamada, and T. Takahashi, Automated parallel synthesis of a protected oligosaccharide library based upon the structure of dimeric Lewis X by one-pot sequential glycosylation, SYNLETT, (2005) 824—828. [Pg.156]


See other pages where Automated parallel synthesis is mentioned: [Pg.126]    [Pg.66]    [Pg.375]    [Pg.205]    [Pg.262]    [Pg.21]    [Pg.22]    [Pg.216]    [Pg.178]    [Pg.261]    [Pg.263]    [Pg.362]    [Pg.396]    [Pg.231]    [Pg.276]    [Pg.92]    [Pg.436]    [Pg.260]    [Pg.53]    [Pg.343]    [Pg.165]    [Pg.572]    [Pg.3419]    [Pg.3423]    [Pg.140]    [Pg.17]    [Pg.18]    [Pg.18]   
See also in sourсe #XX -- [ Pg.12 , Pg.15 , Pg.343 , Pg.366 ]

See also in sourсe #XX -- [ Pg.32 ]




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