High throughput parallel organic synthesis

The Affymax Research Institute has developed an original approach for the synthesis of organic compounds in 96 deep well plates. The high-throughput organic parallel synthesis (HiTOPS) systemP l (Figure 4) utilizes a variety of 96 deep well filtration microtiter plates available from Whatman Polyfiltronics. 

Figure 4 The High-Throughput Organic Parallel Synthesis System with a Synthesis Device Shown on the Left and the Cleavage Device on the Right l...

The main purpose of parallel high-throughput organic synthesis (HTOS) is, as already mentioned in Chapter 4, to prepare focused libraries of discrete compounds that can be used to assess a fast, preliminary stmcture-activity relationship for a specific target. The components of these libraries may vary in number from tens to thousands of compounds therefore different instrumentation and expertise are required depending on the library size. 

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