Autologous chondrocytes

Grande DA, Pitman ML, Peterson L, Menche D, Klein M. The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. 1989 J Orthop Res. 7 208. ... 

ChondroArt Educell (Slovenija) Autologous chondrocytes seeded on an alginate—agarose hydrogel Cartilage defects Marketed... 

NeoCart Histogenics (US) Tissue implant comprised of autologous chondrocytes seeded on a collagen type I scaffold and grown under physiological conditions Cartilage defects Clinical (phase III)... 

Lee, C.R. et aL, Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model, /. Orthop. Res. 21, 272, 2003. 

Litzke, L.E. et al.. Repair of extensive articular cartilage defects in horses by autologous chondrocyte transplantation, Ann. Biomed. Eng. 32, 57,2004. 

Genzyme Cambridge, MA Carticel autologous chondrocytes, Epicel autologous keratinocytes Cartilage defects of die knee, burn wounds Culture of autologous keratinocytes and chondrocytes... 

It is well-known that the identification of several stem cell sources and their isolation promise to revolutionize the concept of regenerative medicine (Conrad and Huss 2005), allowed us to develop numerous cell-based therapies. For cell therapy, either differentiated (e.g., autologous chondrocytes) (Risbud and Sittinger 2002) or undifferentiated (e.g., stem cells) cells (Spangrude 2003, Zeng and Rao 2007) can be used. An implantation at the injury site of freshly isolated cells (e.g., own-patient cells) or cultured cells (differentiated cells alone or in combination with stem cells, and with or without the presence of bioactive molecules) is a possibihty. 

Intervertebral disc (IVD) injuries and articular cartilage damage incurred through injury and disease maybe ameliorated by new cellular therapies designed to restore tissue and decrease pain (Elisseeff et al. 2005, Chen et al. 2006, Vats et al. 2006). One strategy is to use autologous chondrocyte (cartilage cell)... 

Gobbi, A., Kon, E., Berruto, M., Filardo, G., Delcogliano, M., Boldrini, L., Bathan, L., Marcacci, M., 2009. Patellofemoral full-thickness chondral defects treated with second-generation autologous chondrocyte implantation results at 5 years follow-up. The American Journal of Sports Medicine 37, 1083-1092. 

Schneider, U., Rackwitz, L., Andereya, S., Siebenlist, S., Fensky, R, Reichert, J., Loer, L, Barthel, T., Rudert, M., Noth, U., 2011. A prospective multicenter study on the outcome of type I collagen hydrogel-based autologous chondrocyte implantation (CaReS) for the repair of articular cartilage defects in the knee. The American Journal of Sports Medicine 39, 2558-2565. 

Langer, R. and Vacant , J.R (1993). Tissue engineering. Science 260 920-6. Brittberg, M., Lindahl, A., Nilsson, A., Ohlsson, C., Isaksson, O., and Peterson, L. (1994). Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N. Engl. J. Med. 331 889-95. 

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