Gonadotropin releasing hormone receptor

Ballesteros, J. A., Kitanovic, S., Guamieri, F., et al. (1998) Functional microdomains in G protein-coupled receptors The conserved arginine cage motif in the gonadotropin-releasing hormone receptor. J. Biol. Chem. 273,10445-10453. 

Cornea, A. and Michael Conn, P. (2002) Measurement of changes in fluorescence resonance energy transfer between gonadotropin-releasing hormone receptors in response to agonists. Methods 27, 333. 

Gonadotropin-Releasing Hormone Receptor Mutations and Idiopathic Hypogonadotropic Hypogonadism... 

Beranova, M., Oliveira, L. M. B., Bedecarrats, G. Y., et al. (2001) Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. J. Clin. Endocrinol. Metab. 86,1580-1588. 

Layman, L. C., Cohen, D. P., Jin, M., et al. (1998) Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism. Nat. Genet. 18, 14-15. 

Hoffmann, S. H., ter Laak, T, Kuhne, R., ReUander, H., and Beckers, T. (2000) Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding. Mol. Endocrinol. 14, 1099-1115. 

Chauvin, S., Hibert, M., Berault, A., and Counis, R. (2001) Critical implication of transmembrane Phe310, possibly in conjunction with Trp279, in the rat gonadotropin-releasing hormone receptor activation. Biochem. Pharmacol. 62, 329-334. 

Sanno, N., Jin, L., Qian, X., Osamura, R. Y., Scheithauer, B. W., Kovacs, K., and Lloyd, R. V. (1997) Gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor messenger ribonucleic acids expression in nontumorous and neoplastic pituitaries. J. Clin. Endocrinol. Metab. 82, 1974-1982. 

Hapgood JP et al Regulation of expression of mammalian gonadotropin-releasing hormone receptor genes. J Neuroendocrinol 2005 17 619. [PMID 16159375]... 

Blocked Hamster. Biol of Reprod 25 298-302 Adams TE, Norman RL, Spies HG (1981) Gonadotropin-Releasing Hormone Receptor Binding and Pituitary Responsiveness in Estradiol-Primed Monkeys. Science 213 1388-1390... 

Harwood JP, Clayton RN, Catt KJ (1980) Ovarian Gonadotropin-Releasing Hormone Receptors. I. Properties and Inhibition of Luteal Cell Function. Endocrinology 107 407—413... 

Naor Z, Benard O, Seger R. Activation of MAPK cascades by G-protein-coupled receptors the case of gonadotropin-releasing hormone receptor. Trends Endocrinol Metab 2000 11 91-99. 

Idiopathic hypogonadotropic hypogonadism (IHH) consists of those patients without a deficient sense of small, anosmia, or adrenal insufficiency. This subset of IHH results in reproductive failure that may be caused by at least 20 different mutations of the GNRH (gonadotropin-releasing hormone) receptor (GNRHR) gene. 

Simpson BJB, Wu FCW, Sharpe RM (1987) Isolation of human Leydig cells which are highly responsive to hCG. J Clin Endocrinol Metab 65 415-422 Clayton RM, Huhtaniemi IT (1982) Absence of gonadotropin-releasing hormone receptors in human gonadal tissue. Nature 299 56-59... 

Krsmanovic, L.Z., S.S. Stojilkovic, L.M. Mertz, M. Tomic K.J. Catt. 1993. Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic nemons. Proc. NatL Acad. ScL USA 90 3908-12. 

Flanagan, C.A., Zhou, W, Chi, L., Yuen, T., Rodic, V., Robertson, D., Johnson, M., Holland, P., Millar, R.P, Weinstein, H., Mitchell, R., Sealfon, S.C. The functional microdomain in transmembrane helices 2 and 7 regulates expression, activation, and coupling pathways of the gonadotropin-releasing hormone receptor, J. Biol. Chem. 1999,274(41), 28880-6. 

L, Zhu Y-F, Rowbottom M, Ashweek N (2008) Gonadotropin-releasing hormone receptor antagonists and methods relating thereto. WO 2008124610... 

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