Asterric acid

Lee HJ, Lee JH, Hwang BY, Kim HS, Lee JJ (2002) Fungal Metabolites, Asterric Acid Derivatives Inhibit Vascular Endothelial Growth Factor (VEGF)-Induced Tube Formation of HUVECs. J Antibiot 55 552... 

Another publication from Takeda described a series of asterric acid analogues as endothelin antagonists. These compounds, TAN-1415 derivatives, have been patented for the indications of myocardial infarction or renal ischaemia [154]. The only reported activity of the asterric acid itself and close analogues (34) is that they showed inhibition against pressor effects, induced by ET-1 in the rat, at 50 mg/kg i.v. 

Lovastatin and six manufacturing impurities (compactin, asterric acid, lovastatin dimer, dehydrolovastatin, dihydrolovastatin, hydroxy acid lovastatin) were fiilfy resolved on a Cg column (2 = 200 nm for dihydrolovastatin and then 238 nm). A 14-min 60/40 -> 90/10 acetonitrile/water [0.1% H3PO4 at pH 2.2) gradient was used to generate the separation [1483]. A quantitation limit of 0.1% was reported. Four metabolites of lovastatin (6 / -hydroxy-, 3"-hydroxy-, 6 -oxomethylene-, and hydroxy acid lovastatin) were extracted from bile and liver tissues and baseline resolved from the parent compound using a C g column (X = 238 nm). Elution was complete in 25 min when a 30/70 -> 90/10 acetonitrile/water (5mM formic acid) gradient was used. Peak shapes were excellent [1484]. 

Fig. 14. Some fungal metabolites in the geodin-erdin-asterric acid series...

Curtis, R. F., C. H. Hassall, S. Natori, and H. Nishikawa Relationship of the osoic acids to asterric acid. Chem. Ind. (London) 1961, 136O. 

Mahmoodian, a., and C. E. Stickings Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling Isolation of sulochrin, asterric acid, (-f-)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol. Biochem. J. 92, 369 (1964). 

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