Aspirin side effects

One drawback of thrombolytic therapy is a high incidence of reocclusion. In a report using a canine model, inclusion of heparin [9005-49-6] (anticoagulant therapy) in the treatment prevented this side effect (158). The combination of aspirin [50-78-2] (antiplatelet therapy) and streptokinase (thrombolytic therapy) has also shown significant therapeutic advantages (78). Although additional work is needed to estabUsh the thrombolytic advantage of various combinations, preliminary results in this area indicate promise in terms of increased efficacy and reduced side effects. 

The relatively low potency of aspirin in overcoming the symptoms of inflammatory diseases has led to a continuing search for new antiinflammatory agents. Although many more potent agents have been introduced to clinical practice, most of these elicit some side effects that limit their use. Derivatives of iv-aryl anthra-nillic acids have provided a series of quite effective antiinflammatory drugs, the so-called fenamic acids. 

Ticlopidine is slightly more beneficial in stroke prevention than aspirin in both men and women.31,32 The usual recommended dosage is 250 mg orally twice daily. Ticlopidine is costly, and side effects include bone marrow suppression, rash, diarrhea, and an increased cholesterol level. Neutropenia is seen in approximately 2% of patients. Thrombotic thrombocytopenic... 

NSAIDs are more likely to cause GI side effects. The salicylate salts cause fewer GI side effects than aspirin and do not inhibit platelet aggregation. 

A clinical study of 21 females and 21 males used to determine the efficacy of using aspirin dissolved in chloroform which was then applied topically to patients infected with herpes zoster and post-therapeutic neuralgia with painful skin lesions has been reported. When an aspirin/chloroform combination (approximately 43.3 mg/mL) was applied, the only reported side-effect was an occasional burning sensation on the skin as the chloroform evaporated from the skin surface however, the possible impact on other major body organs (liver, kidney, etc.) was not investigated (King 1993). 

Dermal Effects. No reports are available on the toxicity of chloroform to skin after inhalation and oral exposures in humans. Stratum comeum damage was reported after a topical exposure of chloroform of 15 minutes duration for 6 consecutive days (Malten et al. 1968). Chloroform was used as a vehicle for the topical application of aspirin for the treatment of painful herpes zoster lesions in male and female humans. The only reported side-effect was an occasional burning sensation to the skin as the chloroform evaporated after application (King 1993). 

Anti-inflammatory drugs (e.g. aspirin) are beneficial in reducing the pain of arthritis but the side-effect of excess acid secretion is a major problem. Since the drugs are required chronically, there is a risk of development of an ulcer. Unfortunately, a drug that reduced pain of arthritis but minimised acid secretion had severe side-effects and was withdrawn (Chapter 11). 

Q88 Anti-inflammatory doses of aspirin may cause tinnitus and deafness. These side-effects are symptoms of salicylate intoxication. 

Aspirin is acetylsalicylic acid and is used as an antiplatelet agent and for pain relief. Its use for anti-inflammatory effects is limited by the occurrence of side-effects, which include tinnitus and deafness, both features of salicylate poisoning. 

Physicians also know that aspirin can have varying levels of success in treating pain, fever, and other conditions, such that low dosages are very effective in some individuals and not at all effective in others. Also, some patients may experience undesirable or dangerous side effects when they use aspirin. 

Diclofenac possesses all of the properties unique to the series of propionic acid drugs, yet in terms of anti-inflammatory and analgesic strength it exceeds that of aspirin, analgin, and ibnprofen. It is used in acnte rheumatism, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, arthrosis, back pain, neuralgia, and myalgia. It rarely causes side effects. The most common synonym is voltaren. 

CHOLiNE SALiCYLATE Has fever Gl side effects than aspirin. 

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