Aspirin effects

Chinese Herbal Medicines. Many traditional Chinese medicines have been screened for radioprotective activity in experimental animals. In one study of more than a thousand Chinese herbs, a number of agents increased the survival rate of dogs exposed to a lethal dose of y-rays by 30—40%, and some symptoms of radiation injury were ameHorated. These effects are potentially related to stimulation of the hemopoietic and immune systems (130). Extracts of five Chinese dmg plants, as weU as aspirin, effectively protected mice exposed to 7.5—8.0 Gy (750—800 rad) of y-radiation, and increased survival rates by 8—50% (131). Several Chinese traditional medicines, adininistered ip before or after irradiation, protected against Hpid peroxidation in a variety of mouse tissues, including BM, Hver, and spleen, as weU as in mouse Hver microsomal suspensions irradiated in vitro (132). 

Barr, H. M., Streissguth, A. P., Darby, B. L., Sampson, P. D., Prenatal exposure to alcohol, caffeine, tobacco, and aspirin Effects on fine and gross motor performance in 4-year-old children. Developmental-Psychology 26(3), 339-348, 1990. 

ASPIRIN ADRENERGIC NEURONE BLOCKERS, ALPHA-BLOCKERS, CENTRALLY ACTING ANTIHYPERTENSIVES, VASODILATOR ANTIHYPERTENSIVES 1 antihypertensive effect with aspirin effect not noted with low-dose aspirin Aspirin may cause sodium retention and vasoconstriction at possibly both renal and endothelial sites Monitor BP at least weekly until stable when high-dose is aspirin prescribed... 

ASPIRIN ANGIOTENSIN II RECEPTOR BLOCKERS Risk of renal impairment when olmesartan is administered with high-dose (>3 g daily) aspirin. Effect not noted with low-dose aspirin Additive effect on reducing glomerular filtration rate Monitor renal function regularly until stable... 

Figure 12,25 Aspirins effects on prostaglandin synthase-1. Aspirin acts by transferring an acetyl group to a serine residue in prostaglandin synthase-1.

Potentiates aspirin effects on platelets (may be harmful). Absorption is impaired by antacids. Elimination is reduced by cimetidine. 

Gustafson-Svard, C., Lilja, L, HaUbook, O., and Sjodahl, R., Cyclo-oxygenase and colon cancer clues to the aspirin effect Ann. Med., 29,247-252,1997. 

Early Treatment Diabetic Retinopathy Study Report 14. Aspirin effects on mortality and morbidity in patients with diabetes mellitus. JAMA 1992 268 1292-1300. 

DeSchepper PJ, Tjandramaga TB, De Roo H Verhaest L, Daurio C, Steelman SL, Tempero KF. Gastrointestinal blood loss a r diflunisal and after aspirin effect of ethanol. Clin Pharmacol Ther (1978) 23,669-76. 

It is still not clear whether anti-inflammatory drugs such as phenylbutazone and indometacin induce thrombocytopathy, i.e., prolongation of the bleeding time similar to the well-known aspirin effect. 

---