Aspartame-Acesulfame Salt

Aspartame-Acesulfame Salt occurs as a white, crystalline powder. It is sparingly soluble in water and slightly soluble in alcohol. 

Identification An infrared absorption spectrum of a potassium bromide dispersion of Aspartame-Acesulfame Salt exhibits maxima only at the same wavelengths as those of a typical spectrum as shown in the section on Infrared Spectra, using the same test conditions as specified therein. 

Optical (Specific) Rotation Determine as directed under Optical (Specific) Rotation, Appendix HB, using a solution containing 6.2 g of sample in sufficient 15 N formic acid to make 100 mL. Make the determination within 30 min of preparation of the Sample Solution. Divide the calculated specific rotation by 0.646 to correct for the Aspartame content in Aspartame-Acesulfame Salt. 

Aspartame-Acesulfame Salt (Mineral Oil Mull) View Monograph... 

Acetaldehyde Diethyl Acetal 2-Acetyl Thiazole Allyl Phenoxy Acetate Allyl Propionate Aspartame-Acesulfame Salt Borneol... 

Aspartame-Acesulfame Salt, 5, 96 dl-Aspartic Acid, 7 L-Aspartic Acid, 7... 

Acetyl Thiazole, 94 Allyl Phenoxy Acetate, 95 Allyl Propionate, 95 Aspartame-Acesulfame Salt, 96 Borneol, 96... 

Arsenic Specifications Policy, 2 Arsenic Test, 755 Ascorbic Acid, 33 l-Ascorbic Acid, 33 Ascorbyl Palmitate, 34 Ash (Acid-Insoluble), 748 Ash (Total), 748 L-Asparagine, 35 Aspartame, 35, (Sl)4 Aspartame-Acesulfame Salt, (S3)5, 96 dl-Aspartic Acid, 36, (S3)7 l-Aspartic Acid, 37, (S2)l, (S3)7 L-a-Aspartyl-2-methyl ester Compound with 6-Methyl-l,2,3-oxathiazin-4(3H)-one 2,2-Dioxide (1 1), (S3)5 A-L-a-Aspartyl-L-phenylalamnc 1-Methyl Ester, 35, (S1 )4... 

The salt is prepared by heating an 2 1 ratio (w/w) of aspartame and acesulfame-K in solution at acidic pH. Aspartame-acesulfame dissolves completely in saliva and gastric juice. Although this salt it mainly consists of the two approved sweeteners, it is considered as a separate compovmd, which requires specific approval in certain covmtries. In the EU, it is part of the Proposed Amendment to the Sweeteners... 

A-A salt, aspartame-acesulfame NHDC, neohesperldine dihydrochalcone m.p., melting point ADI, acceptable daily intake JECFA, Join Expert Committee on Food Additives of the Agriculture OrganizationAWorld Health Organization SCF, Scientific Food Committee of the European Community. 

Acesulfame-K is a white crystalline powder having a long (six years or more) shelf life. It readily dissolves in water (270 g/L at 20°C). Like saccharin, acesulfame-K is stable to heat over a wide range of pH. At higher concentrations, there is a detectable bitter and metallic off-taste similar to saccharin. Use of the sodium salt of feruHc acid [437-98-4] (FEMA no. 3812) to reduce the bitter aftertaste of acesulfame-K has been described (64). The sweetness potency of acesulfame-K (100 to 200x, depending on the matching sucrose concentration) (63) is considered to be about half that of saccharin, which is about the same as that of aspartame. 

Salt of aspartame and acesulfame. A salt of aspartame and acesul-fame is now available. The product is a chemical combination of aspartame and acesulfame in a ratio of 64 36 on a weight basis. This product was given 2 years temporary national approval in the United Kingdom (Statutory Instrument 2003 number 1182). It also has temporary approval in The Netherlands (Staatscourant, 17 July 2002), and it can be used in the United States, Canada, China, Mexico and Russia. In 2004, amendment of the EU Sweetener Regulation saw extension of the approval to all EU markets. In solution, the salt breaks up to form aspartame and acesulfame. The relative sweetness is 350 (HSC, 2003). 

With the general name of cyclohexylsulphamate, this sweetener was discovered in 1937 by Michael Sveda at the University of Illinois. The sodium salt is the most commonly used form. It is a white crystalline salt with good solubility. The relative sweetness of cyclamate is comparatively low, at approximately 35, in most food systems (Bakal, 1983). The taste quality of cyclamate as a sole sweetener has a slow onset time and can have a sweet/sour aftertaste at high concentrations (Franta et al., 1986). Sweetness quality is greatly unproved in combination with other sweeteners. Cyclamate is synergistic with acesulfame K (Von Rymon Lipinsky, 1985), aspartame (Searle, 1971), saccharin (Von Rymon Lipinsky, 1987) and sucralose (Tate Lyle Pic, 2002). 

This intense sweetener (8) is quoted as having the same effective sweetness as aspartame, but unlike aspartame it is sufficiently heat stable that it can be added at the beginning of the boil in high-boiled products. If a product with the same amount of acesulfame K is compared with one based on aspartame the taste will be different. In practice acesulfame K is not normally used on its own but is sometimes used with aspartame. Chemically, acesulfame K is the potassium salt of 6-methyl-l,2,3-oxathiazine-4(3//)-one-2,2 dioxide or 3,4-dihydro-6-methyl-l,2,3-oxathiazine-4-one 2,2-dioxide. It can be regarded as a derivative of acetoacetic acid. The empirical formula is C4H4N04KS and its molecular weight is 201.2. 

A-A salt CisHasOgNsS 457.46 Covered by the ADI values previously established for aspartame and acesulfame-K ... 

---