Ascorbyl phosphate

One of the main problems of topical application of vitamin C is that it is extremly unstable, so hydrophilic derivatives like sodium ascorbyl phosphate and lipophilic esters with fatty acids were synthesized to improve stability.43,44 However, an efficient increase in vitamin C levels after topical application of different ascorbic acid derivatives including magnesium ascorbyl phosphate, ascorbyl-6-palmitate, and dehydroascorbic acid to porcine skin could not be shown.42... 

Varvaresou, A. et al. Development and validation of a reversed-phase ion-pair liquid chromatography method for the determination of magnesium ascorbyl phosphate and melatonin in cosmetic creams. Anal. Chim. Acta 2006, 573-574, 284—290. 

Magnesium ascorbyl phosphate (6) was used as reference compound for the RP-HPLC-UVD determination of sodium risedronate (68) in pharmaceutical preparations . Co(II) reacts with 2,2 -bipyridylketone-2-picolylimine in the presence of Na L-ascorbate in a weakly alkaline solution to form a blue water-soluble complex with the absorption maximum at ca 580 nm. The absorbance at 580 nm is proportional to the concentration of Co(II) in the range 0.05-2.5 mg L , with RSD = 0.46%. Ni(II) and Cu(II) were tolerated up to 20 and 10 mg L , respectively, in the presence of Na citrate . 

Magnesium ascorbyl phosphate (MAP) is more effective than ascorbyl palmitate (AP), as the protection of its active function by esterification protects the MAP against oxidation and provides an antioxidant effect that is of better quality and longer lasting than that of ascorbyl palmitate, a molecule in which the enediol function of the 2 carbon atom is not protected by esterification. 

For example, the possibihty of including products in liposomes, cyclodextrins, nanosomes or multilayers and using specific molecules such as arbutin, magnesium ascorbyl phosphate, etc. 

Spiclin P, Homar M, Zupandid-Valant A, Gasperlin M. Sodium ascorbyl phosphate in topical microemulsions. International Journal of Pharmaceutics. 2003 256(l) 65-73. 

Ascorbic acid, magnesium salt L-Ascorbic acid magnesium salt. See Magnesium ascorbate Ascorbic acid, monoester with phosphoric acid, magnesium salt (2 3). See Magnesium ascorbyl phosphate... 

Storage Store in cool, dry place keep tightly closed protect from moisture Uses Antioxidant in cosmetics Manuf./Distrib. Sigma Magnesium ascorbyl phosphate CAS 114040-31-2... 

Nikkol TO-30. See Polysorbate 85 Nikkol TO-106. See PEG-6 sorbitan oleate Nikkol TP-10. See Polysorbate 40 Nikkol TS-10. See Polysorbate 60 Nikkol TS-30. See Polysorbate 65 Nikkol TS-106. See PEG-6 sorbitan stearate Nikkol TW-10. See PEG-10 lanolin Nikkol TW-20. See PEG-20 lanolin Nikkol TW-30. See PEG-30 lanolin Nikkol VC-PMG. See Magnesium ascorbyl phosphate... 

Magnesium ascorbate Magnesium ascorbyl phosphate Melanin 2-Mercaptopropionic acid Methyl gallate... 

Magnesium ascorbyl phosphate Nikkol VC-PMG 114355-43-0 Nikkol Hexaglyn PR-15 Polyglyceryl-6 polyricinoleate 114369-43-6 Fenbuconazole 115340-77-7... 

SHIBAYAMA, H., HISAMA, M., MATSUDA, S., OHTSUKI, M. IWAKI, M. 2008. Effect of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate on human dermal fibroblasts Increased collagen synthesis and inhibition of MMP-1. Biol Pharm Bull, 31, 563-8. 

Sodium (or magnesium) Ascorbyl phosphate (Vitamin C derivative)... 

Key abbreviation AA, ascorbic acid ADP, ascorbyl dipalmitate AG, ascorbyl glucoside AP, ascorbyl palmitate ARB, arbutin AZA, azelaic acid HQ, hydroquinone HQDM, hydroquinone dimethyl ether HQMB, hydroquinone monobenzyl ether HQME, hydroquinone monoethyl ether HQMM, hydroquinone monomethyl ether HQMP, hydroquinone monopropyl ether HQMPh, hydroquinone monophenyl ether KA, kojic acid MAP, magnesium ascorbyl phosphate. 

Vitamins (see Section 8.6), often added to cosmetic formulations, act as antioxidant preservatives due to their general antioxidant properties towards free radicals. Examples are retinol (vitamin A) and its precursor j5-carotene, tocopherol (vitamin E) and ascorbic acid (vitamin C). Moreover, vitamin derivatives, such as retinyl acetate, retinyl palmitate, ascorbyl palmitate, magnesium ascorbyl phosphate and tocopheryl acetate among others, are also employed as antioxidant agents. 

Some derivatives of vitamin C, e.g. sodium ascorbyl phosphate, have the benefit of being stable in cosmetic formulations and exerting the favourable effects of vitamin C when applied on the skin. The most commonly used are salts of ascorbic acid sodium or magnesium ascorbate, sodium or magnesium ascorbyl phosphate, ascorbyl glucoside and ascorbyl pahnitate. 

One of the most useful is sodium ascorbyl phosphate (SAP) some major cosmetic activities of this compound are described briefly below. 

Ascorbic acid plays an important role in the regeneration of vitamin E from vitamin E radical. This recycling effect has been specifically shown in skin. Therefore, sun-care products should ideally combine vitamin E acetate and sodium ascorbyl phosphate to protect the skin from harmful UV irradiation. To test this, a new method was developed by Hanson (2003) to visualize UV-induced free radical formation in human skin. Results show that SAP in combination with vitamin E acetate reduces the formation of free radicals in the skin by almost 50% compared to a placebo sun-care formulation having an SPF of 8. 

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