Magnesium trisilicate ascorbic acid

The Influence of Magnesium Trisilicate and Silicon Dioxide on the Thermal Degradation of Ascorbic Acid... [Pg.24]

Ascorbic acid (Sigma), magnesium stearate (CIA-Estearina Parananheci), magnesium trisilicate (Farmar), and Si02 (Cab-O-Sd) were used without further purification. [Pg.24]

Ascorbic acid samples as well as binary mixtures of ascorbic acid and the considered excipients were investigated. The binary mixtures were prepared taking into account the shoichiometry generally used for the preparation of ascorbic acid tablets ascorbic acid (500 mg, of a 100 mesh sample), magnesium stearate (6.7 mg), magnesium trisilicate (13.3 mg), and Si02 (1.0mg). The compounds were mixed in a mortar. [Pg.24]

Based on the TG and DSC experimental results it can be concluded that the excipients, that is, magnesium stearate, magnesium trisilicate, and Si02, have no substantial influences on the thermal stabihty of ascorbic acid. This result shows that the three compounds can be used (at least from a thermal point of view) as excipients, with no restrictions, for ascorbic acid tablet formulations, since they will not provoke or accelerate the thermal degradation of ascorbic acid. However, by comparison of Tables 3.5 and 3.7, it is evident that the temperature of the... [Pg.29]

Figure 3.19 TG curves for (a) ascorbic acid, (b) magnesium trisilicate, and (c) ascorbic acid/ trisilicate binary mixture.

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