Aryl-substituted derivative

Classic A/-heterocychc ligands, eg, bipyridyl (bipy), terpyridyl, imidazole, pyrazine, phenanthroline, piperazine (including alkyl- and aryl-substituted derivatives), and polypyrazol-l-yl-borates (bis, tris, and tetra), have all been found to coordinate Th(IV) chlorides, perchlorates, and nitrates. The tripodal hydrotris(pyrazolyl)borates, HBPz, have been used to stabilize organometaHic complexes (31). Bis-porphyrin Th(IV) "sandwich" complexes have been... 

In a similar manner, phthalazine or its alkyl- or aryl-substituted derivatives are obtainable from 1,2-diacylarenes (Scheme 76). Phthalaldehydic acid and its analogs are transformed by hydrazines into the corresponding phthalazin-l(2//)-ones. Phthalazin-l(2iT)-one itself is prepared from naphthalene by oxidation, subsequent treatment with hydrazine and decarboxylation as shown in Scheme 77 (55YZ1423,64FRP1335759). 4-Substituted phthalazin-l(2iT)-ones are prepared in a similar way from 2-acylbenzoic acids. 3-Hydroxyphthalides,... 

Dediazoniations which give aryl-addition or aryl-substitution derivatives of compounds with double bonds are discussed in this and the following section. Reactions at the C or S atom of carbonyl or sulfonyl groups are treated in this section and those at C = C double bonds in Section 10.9. 

The preparation of phenyldioxophosphorane ( benzenephosphonic anhydride ) was reported as long ago as the turn of the century. It was thought to arise on reaction of benzenephosphonic acid with benzenephosphonic dichloride40) aryl-substituted derivatives were also believed to have been formed by the same reaction 41 ... 

The molecular structure of the bicyclic framework in 108 is best described as a dithiatriazine bridged by an -N=S=N- group. The aryl-substituted derivatives 108 (R=aryl) form 2 1 inclusion complexes with aromatic fluorocarbons or hydrocarbons.266 In solution, the phenyl derivative 108 (R=Ph) is fluxional.258... 

The aryl-substituted derivatives of [Bi(SeC6H2R3-2,4,6)3] (R = Me, Pr, Bu) are the only isolated examples of selenolate complexes. They have been characterized by mp, elemental analysis, NMR spectroscopy, and thermal gravimetric analysis, and the solid-state structure of the isopropyl-substituted derivative reveals a tricoordinate environment for bismuth [Bi-Se 2.630(8)-2.711(8) A Se-Bi-Se 92.3(2)-103.3(2)°], imposed by the steric bulk of the ligands (38). 

The preparation of biologically active [l,2,4]triazolo[l,5- ]pyrazines has been reported recently. The reaction routes are shown in Scheme 50. Dowling et al. reported <2005BML4809> the synthesis of aryl-substituted derivatives 411. The first step was the transformation of the 2-aminopyrazine compound 409 to an amidine 410, which was subjected... 

Further stereoisomeric derivatives of the 1,3-oxazines 167 (n = 1, 2 Ph a or j8) (82MI1 90T6859), and of 168-171 (diendo and diexo) (83JHC1181 84JHC1373 87MRC584) and several of their 4-aryl-substituted derivatives, were also prepared by ring closure with imidates (90MRC1045). 

The question of configurational stability has been investigated first for vinylidene carbenoids and, more recently, for alkylcarbenoids. Vinyl anions are usually considered to be configurationally stable" ° the calculated inversion barrier of the ethenyl anion 10 (R = H) is about 35 kcal mol (equation 4)" . Concerning lithioalkenes, this configurational stability has been confirmed experimentally for a-hydrogen, a-alkyl and a-aryl substituted derivatives . The inversion of vinylidene lithium carbenoids was already... 

Aminopyrazolo[3,4-d]pyrimidines 257 were converted into the corresponding 4-aryl substituted derivatives 259 via treatment with alkyl nitrites and boiling in aromatic solvent. The isomer distribution of 259 prepared by these route was that predicted for a radical intermediate (ortho, meta, and para). The structure of isomers was established by H-NMR. Unusual fragmentation products were isolated these probably result from collapse of the radical intermediate 258 (83JOC4605). Methylation of 257 takes place at either N-1 or N-2. Further methylation affords methylamino derivatives structures of the products were established by C-NMR as well as by chemical methods (75JOC1822). 

Interestingly, chloropalladation reaction of the more constrained cu-7-methylenebicy-clo[4.1.0]heptane did not afford the expected dis-in kinetic product but rather the rearranged to >/ to rf ) thermodynamic isomer whose structure (as the acac mononuclear complex) was confirmed by X-ray crystallographic analysis (equation 327)394. More recently, 1-aryl-substituted derivatives of this bicyclic methylenecyclopropane (equation... 

Among other nickel chelates with unsaturated five-member coordination units, we point out the complexes of thioarylhydrazones 464 [814-816] and dithiocarbazones 465 [817-820] of benzaldehyde and its aryl-substituted derivatives ... 

Complexes of salicylideneiminoalcohols 884-889 (X = Y = 0, m=, n— 4) are widely known. Earlier works on the synthesis, structure, and properties of these ICC are discussed in several reviews [144,215,216] and also reported in more recent publications [217-221]. To develop this area, a series of complex compounds of aryl-substituted derivatives of salicylidene(naphthalidene)monoethanolamines 891 was isolated (4.54) and direct x-ray diffraction proofs of structures of type 887 were obtained [217], The structure of 891 (R = 3,5-Cl2) was confirmed by x-ray diffraction [217] ... 

The combination of dithiolene and diimine chelating ligands in square-planar ds complexes gives rise to a unique CT excited state, and complexes of this class have been the subject of a rich and growing amount of research in recent years. The Pt(diimine)(dithiolene) complexes were among the earliest examples of emission from square-planar metal complexes in fluid solution. Luminescence from room temperature solutions of Pt(diimine)(mnt) complexes with diimine = bpy, phen, or an alkyl- or aryl-substituted derivative was reported in 1990 by Zuleta et al. (98, 99), following an initial report on similar complexes with a 1,1-dithiolate. 

Related 1,3-oxazepines have been obtained from irradiation of many other heterocyclic A-oxides including pyridine A-oxides, isoquinoline A-oxides, quinoxaline A-oxides, quinazoline A-oxides, phenanthridine A-oxides, benzophenazine A-oxides, and acridine A-oxides.4 However, the reported yields are variable and have generally been higher for phenyl and other aryl-substituted derivatives. 

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