Aryl halides with halide ions

The synthesis of aromatic azides (Scheme 37) from aryl halides with azide ions (SxAr) is particularly successful with systems that carry an activating substituent, an electron-withdrawing group, either in the ortho or the para position relative to the potential leaving group." -" A table with numerous examples can be found in the literature." Fluoride ion as a leaving group is superior to the other halides. Dipolar aprotic solvents, such as DMF for instance, have their special merits in these transformations, too. The reaction of 2,4- or 2,6-dinitroaryl halides with azide ions was shown to be accelerated in micelles or in the presence of quaternary ammonium salts." ... 

Aryl Halides from Diazonium Ion Intermediates. Replacement of diazonium groups by halides is a valuable alternative to direct halogenation for the preparation of aryl halides. Aryl bromides and chlorides are usually prepared by a reaction using the appropriate Cu(I) salt, which is known as the Sandmeyer reaction. Under the classic conditions, the diazonium salt is added to a hot acidic solution of the cuprous halide.99 The Sandmeyer reaction occurs by an oxidative addition reaction of the diazonium ion with Cu(I) and halide transfer from a Cu(III) intermediate. 

The photoinduced reactions of aryl halides with the thiourea anion afford arene thiolate ions in DMSO. These species can be used without isolation for... 

Ce4+ can be also used for the same type of reaction, since it is a strong one-electron oxidant. Generation of sp2 carbon-centered radicals such as aryl radicals, is not so easy, except for the reactions of aryl halides with Bu3SnH or Ph4Si2H2. However, treatment of arylhydrazines with Cu2+ generates aryl radicals through the initial oxidation to the arenediazonium ion with Cu2+, and subsequent SET from Cu+. Aryl radicals are much more reactive than alkyl radicals, and rapidly react with alkenes or imines as shown below (eq. 4.22) [60-63]. 

Intermolecular photoreaction of an aryl halide with another aromatic compound may lead to the formation of biaryls. In this section several examples of such reactions will be discussed. In some cases, information concerning the reaction mechanism is available but the depth to which mechanisms have been investigated varies greatly. In many cases aryl radicals formed by homolysis of the carbon-halogen bond are the reactive species. Such radicals may also be produced via electron transfer, followed by departure of halide anion. In some cases aryl cations have been proposed as intermediates. Intermolecular bond formation may also be preceded by charge transfer within an exciplex or by formation of radical ion pairs. 

Acceleration by KI in the substitution reaction of aryl halides with potassium diethyl phosphite or with the 2-naphthoxide ion has also been explained on the basis of an ET through the exciplex of the charge-transfer complex formed between the aryl halide and the iodide ions34a. It has also been reported that iodide ions catalysed the photostimulated reaction of bromoarenes with diethyl phosphite ion34b. 

By far one of the most important reactions through the S l mechanism is formation of a C—C bond by the reaction of aryl halides with carbanions derived from hydrocarbons, ketones, esters, amides, nitriles and even, with some limitations, from aldehydes. The reactions of cyanide ions and carbonyl complexes of Co and Fe also form a new C—C bond. 

In the presence of an electron rich donor molecule an alternative to direct fission or reaction via an excimer is the formation of an exciplex or radical anion/radical cation ion pair (Eq. 2). The radical anion has been viewed as the key intermediate which undergoes fission to aryl radical and halide ion (Eq. 3). With polyhaloarenes there is an additional option. A polychloroarene radical anion, for example, has two possible modes for bond fission (a) fission to produce aryl radical and chloride ion or (b) fission to form an aryl carbanion and chlorine atom (Scheme 6). The options for fragmentation of a haloarene radical anion... 

After the reaction of an aryl halide with cuprous cyanide to form a nitrile, added ethylenediamine complexes with cuprous and cupric ions and facilitates isolation of the nitrile (see Ferric chloride). 

An unambiguous example is the nucleophilic substitution of l-alkenyl(aryl)io-donium salts with halide ions (Scheme 9). l-Decenyl(phenyl)iodonium tetra-... 

For fast reactions of the type represented by reaction 13.2, carried out under the conditions stated earlier, micromixing becomes the dominant consideration. However, studies on the effect of micromixing in such reactions are sparse. Some examples are as follows nitration of aromatic componds in general (Schofield, 1980), potassium metal-provoked reactions of aryl halides with amide and acetone enolate ions (Tremelling and Bunnett, 1980X coupling of 1-naphthol with diazotized sulfanilic acid (Bourne et al., 1981, 1985), reactions of o-(3-butenyl)-halobenzenes and 6-bromo-1-hexene with alkali metals in ammonia/terr-butyl alcohol solution (Meijs et al., 1986), and monoacylation of symmetrical diamines (Jacobson et al., 1987). In some fast reactions, hydrogen ions are produced. 

It should also be noted that copper-catalyzed Ullmann-type coupling of aryl halides with amines yields substituted products [206], and reaction with diphenylamine has been used to form triaryl-amines [207], Triarylamines may also be formed in a variation of the Meyers reaction [47] by displacement by lithium amides of fluoro- or methoxy-substituents activated by an ort/io-ester function [208], The oxidation of a-adducts is discussed in Chapter 11, but it should also be mentioned that aminated products may also be produced by the oxidation of adducts formed by the addition of amide or alkylamide ions at ring carbon atoms carrying hydrogen [209]. 

Reaction of Arylamines Copper-catalyzed C—N coupling affords powerful tool for the synthesis of nitrogenated compounds [33]. In 1987, Paine reported soluble cuprous ion as the active catalytic species in Ullmann coupling [34]. Soluble air-stable copper(I) complex, Cu(PPh3)jBr, has been used for the synthesis of functionalized diaryl and triaryl amines (Scheme 20.17) [35]. Copper(I) complexes 7-8 and CuI-PBu have been employed for the coupling of aryl halides with aiyl amines [36, 37]. The catalyst with PBu could be used for the coupling of less reactive aiyl chlorides in the presence of KOTlu. 

Sulfonation with Sulfuric Acid and Sulfur Triozide. Various mechanisms for the reaction of aromatic hydrocarbons or aryl halides with sulfuric acid or with sulfur trioxide have been proposed. Since.the reaction is heterogeneous, it is not favorable for experimental study. Solvents that dissolve sulfuric acid or sulfur trioxide form addition compounds with the reagent hence any conclusion drawn from a homogene ous sulfonation might not be applicable to the ordinary sulfonation. One possibility is that an electrophilic reagent such as sulfur trioxide with its relatively positive sulfur atom or an ion such as HOaS" " in the case of sulfuric acid attacks the negative center of the polarized form of the hydrocarbon, as illustrated for benzene. 

The nucleophilic displacement reaction of both alkyl and aryl halides by cyanide ions in dipolar aprotic solvents has been studied extensively [1,6,11]. This reaction can be visualized as a condensation of NaCN with RX to give RCN. In the alkyl series, sodium cyanide is usually used with dimethyl sulfoxide or dimethylformamide as the solvent [12-20]. Some examples from Friedman and Shechter [1] are reproduced in Table II. 

The first step in the reaction of an alkyl aryl ether with a hydrogen halide is pro tonation of oxygen to form an alkylaryloxonium ion... 

A significant modification in the stereochemistry is observed when the double bond is conjugated with a group that can stabilize a carbocation intermediate. Most of the specific cases involve an aryl substituent. Examples of alkenes that give primarily syn addition are Z- and -l-phenylpropene, Z- and - -<-butylstyrene, l-phenyl-4-/-butylcyclohex-ene, and indene. The mechanism proposed for these additions features an ion pair as the key intermediate. Because of the greater stability of the carbocations in these molecules, concerted attack by halide ion is not required for complete carbon-hydrogen bond formation. If the ion pair formed by alkene protonation collapses to product faster than reorientation takes place, the result will be syn addition, since the proton and halide ion are initially on the same side of the molecule. 

Nucleophilic substitution by cyanide ion (Sections 8.1, 8.13) Cyanide ion is a good nucleophile and reacts with alkyl halides to give nitriles. The reaction is of the S m2 type and is limited to primary and secondary alkyl halides. Tertiary alkyl halides undergo elimination aryl and vinyl halides do not react. 

R—N=N=. Aryl diazonium ions are formed by treatment of primary aromatic amines with nitrous acid. They are extremely useful in the preparation of aryl halides, phenols, and aryl cyanides. 

In the arylations of enamines with very reactive aryl halides (352,370) such as 2,4-dinitrochlorobenzene, the closely related mechanistic pathway of addition of the enamine to the aromatic system, followed by elimination of halide ion, can be assumed. The use of n-nitroarylhalides furnishes compounds which can be converted to indolic products by reductive cycliza-tion. Less reactive aryl halides, such as p-nitrochlorobenzene, lead only to N-arylation or oxidation products of the enamines under more vigorous conditions. 

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