Artemisia leucodes

Two comparable procedures of reverse-phase HPLC with spectrophotometric detection at 254 nm, with mobile phases of MeOH-0.05 M acetate buffer (70 30) or THF-0.01 M phosphate buffer (55 45), were used to resolve leukomisin, matricarin, austricin, anhydroaustricin, and potential antiarteriosclerotic sesquiterpene lactones from aerial parts of Artemisia leucodes. 

The Laboratory of Lactones, Coumarins, and Terpenoids (headed by Prof. G.P Sidyakin) studied various plants for lactone content, particularly for the lactones leucomisine and austricine, which were isolated from Artemisia leucodes. Both lactones possess pronounced anti-inflammatory action. As a compound possessing pronounced angio-protective, hypolipidemic, hypo-cholesterolemic, and anti-inflammatory actions, leucomisine has passed medical tests and has been introduced into medical practice under the preparation name Oligvon. Since 1970, systematic studies of chemical compounds found in various species of the genus Ferula, which grows in the territory of Uzbekistan and adjacent republics, have been conducted. As a result, more than 50 species of Ferula have been investigated, from which more than 250 new terpenoids, coumarins, and esters have been isolated and their chemical structures determined. Natural esters of mono- and sesquiterpene alcohols with aromatic acids were discovered for the first time in this lab (Kurmukov and Akhmedkhodzhaeva 1994). 

Tursunova NV, Syrov VN, Khushbaktova ZA, Mukhamatkhanova RF, Sham yanov ID, Nabiev AN (2002) Effect of the total sesquiterpe-noid extract from Artemisia leucodes on cholepoietic processes in rat liver in the normal state and during experimental hepatitis. Pharm Chem J 36(2) 37-39... 

Tye A, Baldesbeiger R, Lapidus JB, Patil PN (1967) Steric aspects of adrenergic drugs. VI. Beta adrenergic effects of ephedrine isomers. J Pharmacol Exp Ther 157 356-362 Ul chenko NT, Glushenkova A1 (2(X)1) Oxygenated fatty acids from neutral lipids of Artemisia leucodes seeds. Chem Nat Compd 37(5) 406-408... 

Isol. from Artemisia tilesii, A. austriaca, A. leucodes, A. juncea and Achillea lanulosa. Cryst. -I- IH2O (C6H6/Me2CO). Mp 123-125°, Mp 143-146° (double Mp, hydrate). 

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