Arachidonate-5-lipoxygenases

Payne, A.N., Garland, L.G., Lees, I.W. and Salmon, J.A. (1988). Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids effects on bronchial anaphylaxis in anaesthetised guinea-pigs. Br. J. Pharmacol. 94, 540-546. 

This iron-dependent enzyme [EC 1.13.11.34], better known as arachidonate 5-lipoxygenase and occasionally referred to as leukotriene A4 synthase, catalyzes the reaction of arachidonate with dioxygen to produce (6 , 8Z,1 lZ,14Z)-(5S)-5-hydroperoxyicosa-6,8,ll, 14-tetraenoate, which rapidly converts to leukotriene A4. 

HYDRATION WATER a-L-ARABINOFURANOSIDASE d-ARABINOKINASE ARABINONATE DEHYDRATASE ARABINOSE ISOMERASE ARABINOSE-5-PHOSPHATE ISOMERASE Arachidonate 5-lipoxygenase, 5-LIPOXYGENASE ARACHIDONYL-CoA SYNTHETASE Arene oxide intermediate,... 

CSOll Sekine, T., Y. Arai, F. Ikegami, Y. Fujii, S. Shindo, T. Yanagisawa, Y. Ishida, S. Okonogi and 1. Murakoshi. Isolation of camelliaside C from tea seed cake and inhibitory effects of its derivatives on arachidonate 5-lipoxygenase. Chem Pharm Bull 1993 41(6) 1185-1187. 

Arachidonate 12-lipoxygenase inhibition. Essential oil of the unripe fruit was active on platelets, IC50 7 (Xg/mL Arachidonate 5-lipoxygenase inhibition. 

Seven Artocarpus flavonoids and morusin (3) were tested for their inhibitory actions on arachidonate-5-lipoxygenase purified from porcine leukocyte [84]. As shown in Fig. (13), the IC50 values varied depending on the structural modification of the compound. The compounds having three hydroxyl groups at positions 2, 4, and 5 on the B ring (compounds 7, 8, 52 and 55) were more potent inhibitors. Thus, the vicinal diol partial structure was important for 5-lipoxygenase inhibition. 

Inhibitory effects (IC30 SD, N=3, pmol/L) on arachidonate 5-lipoxygenase activity ... 

Ghosh J. 2003. Inhibition of arachidonate 5-lipoxygenase triggers prostate cancer cell death through rapid activation of c-Jun N-terminal kinase. Biochem Biophys Res Commun 307 342-349. 

Yoshimoto, T., Furukawa, M., Yamamoto, S., Horie, T., and Watanabe-Kohno, S. Flavonoids Potent inhibitors of arachidonate 5-lipoxygenase. Biochem Biophys Res Com-mun, 116, 612-618, 1983. 

Iwakami, S., Shibuya, M., Tseng, C.F., Hanaoka, F. and Sankawa, U. (1986) Inhibition of arachidonate 5-lipoxygenase by phenolic compounds. Chemical and Pharmaceutical Bulletin 34, 3960-3963. 

P-Adrenergic receptor Angiotensinogen and receptor Arachidonate 5-lipoxygenase Apolipoprotein E... 

TsukadaT, NakashimaK, Shirakawa S. Arachidonate 5-lipoxygenase inhibitors show potent antiproliferative effects on human leukemia cell lines. Biochem Biophys Res Commun. 140 (1986) 832-836. 

Dwyer, J.H. et al., Arachidonate 5-lipoxygenase promoter genotype, dietary arachi-donic acid, and atherosclerosis, N. Engl. J. Med., 350, 29, 2004. 

Interaction of n-6 and n-3 Fatty Acids with Arachidonate 5-Lipoxygenase... 

INTERACTION OF N-6 AND N-3 FATTY ACIDS WITH ARACHIDONATE 5-LIPOXYGENASE GENE PROMOTER... 

Any of a series of two or more different genes that may occupy the same position or locus on a specific chromosome Arachidonate 5-lipoxygenase gene promoter Apolipoprotein A and Apolipoprotein E Cne of the pairs of chemical bases joined by hydrogen bonds that connect the complementary strands of a DNA molecule or of an RNA molecule that has two strands The genetic constitution of an individual referring to either a gene combination at one specified locus or any specified combination of loci Hepatic lipase... 

Ghosh, J., and Meyers, C.E. (1998) Inhibition of Arachidonate-5-Lipoxygenase Triggers Massive Apoptosis in Human Prostate Cancer Cells, Proc. Natl. Acad. Sci. USA 95,13182-13187. 

Schroder, J. M. (1989) The monocyte-derived neutrophil activating peptide (NAP/interleu-kin 8) stimulates human neutrophil arachidonate-5-lipoxygenase, but not the release of cellular arachldonate. J. Exp. Med. 170, 847-863. 

Lipoxygenases (originally termed lipoxidases) were discovered in higher plants before the first reports on their presence in mammalian cells [1-4]. Nevertheless, the first clear biological function of a lipoxygenase was established for a mammalian enzyme (the arachidonate 5-lipoxygenase) when the biosynthesis of leukotrienes was elucidated [5]. More recently, research into plant lipoxygenases has intensified. 

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