Arachidonate-5-lipoxygenases origin

Lipoxygenases (originally termed lipoxidases) were discovered in higher plants before the first reports on their presence in mammalian cells [1-4]. Nevertheless, the first clear biological function of a lipoxygenase was established for a mammalian enzyme (the arachidonate 5-lipoxygenase) when the biosynthesis of leukotrienes was elucidated [5]. More recently, research into plant lipoxygenases has intensified. 

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