Plant lipoxygenase

Hexenol ( leaf alcohol ) Linolenic acid Soy lipoxygenase + plant hydroperoxide lyase + baker s yeast 4 g kg 5-101 year (also by isolation from plant oils) Addition of baker s yeast to obtain the alcohol without yeast the aldehyde is the major product [60, 66]... 

Lipoxygenase has been reported in many plants (Table I). Because the information is scattered this list is not comprehensive, and priorities of recognition are not necessarily indicated. While legumes are frequently reported to be lipoxygenase plants, such plants may be found throughout many other phyla. 

At the end of the reaction, hydroperoxide can be easily recovered in the aqueous phase (98-99%) after its separation from the organic phase and precipitation of the enzymes. The hydroperoxides obtained are highly reactive molecules [109]. They are intermediate compounds in the lipoxygenase pathway in plants, precursors for the synthesis of hydroxy-fatty acids (i.e., ( + )-coriolic acid [38,110], and regulators of the prostaglandins biosynthesis [111-113]. 

Encompassing approx 6000 medicinal plant species, the medicinal flora of Asia and the Pacific comprise a fantastic source of pharmacologically active products, and the number of plant species principally used for the treatment of inflammation can be estimated to be more that 380. This chapter will focus on the potentials of medicinal plants of Asia as a source of original anti-inflammatory drugs, with particular interest payed to inhibitors of phospholipase A2, COX, lipoxygenases, elastase, and NOS. 

Lipoxygenases, which catalyse the oxidation of unsaturated fatty acids containing the cis,cis-l,4-pentadiene moiety to the corresponding 1 -hydroperoxy-f rans,ds-2,4-diene (Table 2.3), are widely distributed in plants and animals. The mammalian... 

Feussner I and Wasternack C. 2002. The lipoxygenase pathway. Annu Rev Plant Physiol Plant Mol Biol... 

Kolomiets MV, Hannapel DJ, Chen H, Tymeson M and Gladon RJ. 2001. Lipoxygenase is involved in the control of potato tuber development. Plant Cell 13 613-626. 

Liavonchanka A and Feussner, I. 2006. Lipoxygenases occurrence, functions and catalysis. J Plant Physiol 163 348-357. 

Porta H and Rocha-Sosa M. 2002. Plant lipoxygenases. Physiological and molecular features. Plant Physiol 130 15-21. 

Kausch KD, Handa AK. Molecular cloning of a ripening-specific lipoxygenase and its expression during wild-type and mutant tomato fruit development. Plant Physiol 1997 113 1041-1050. 

Feussner, L, Wasternaek, C. (2002). The lipoxygenase pathway. Anna. Rev. Plant Biol, 53,215-291. 

In plants the 13-hydroperoxide produced from linolenic acid by lipoxygenase (Sect. 23.4.1.2) can be converted to the allene oxide by allene oxide synthase followed by cyclisation, reduction and -oxidation to form jasmonic acid, an important plant growth factor the corresponding methyl jasmonate is a valuable flavour and fragrance compound that imparts a sweet-floral, jasmine-like note... 

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