Approaches for inhibiting

Braisted, A.C., Hyde, J., McDowell, R.S., Randal, M., Waal, N.D., Wilkinson, J., Yu, C.H., Arkin, M.R. Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2 an approach for inhibiting protein-protein... 

Supramolecular Approaches for Inhibition of Protein-Protein and Protein-DNA Interactions... 

While there are many examples of macrocyclic structures designed to selectively bind protein surfaces, we highlight four in this section that demonstrate general strategies for designing supramolecular systems for this purpose. For more detailed and encompassing description of research in this area, we refer the reader to a number of excellent reviews" " as well as another article in this series (see Supramolecular Approaches for Inhibition of Protein-Protein and Protein-DNA Interactions, Supramolecular Aspects of Chemical Biology). 

Another approach for inhibition of carbon formation is to retard the full dissociation of the hydrocarbon into adsorbed carbon atoms. The presence of potassium on a nickel catalyst results in a significant increase in the induction period for nucleation of carbon whiskers (refer to Figure 5.6). It means that potassium works as promoter also without the presence of water. 

Other approaches to inhibiting intramolecular cycli2ations of erythromycin have also proven successhil. Erom a series of O-alkyl derivatives of erythromycin, clarithromycin (6-0-methylerythromycin) (37) was selected for clinical development (146,147). Another approach replaced the C-8 proton of erythromycin with duorine, which was accompHshed by both chemical and bioconversion methods to yield durithromycin (38) (148). 

There are three principal gene therapeutic approaches for viral diseases. First, several genes that inhibit virus replication have been developed. This approach has been termed intracellular immunization (Baltimore 1988). Second, genetic approaches... 

The dimerisation energy for derivatives of 2 (ca. 35 kJ mol-1) is considerable, particularly in relation to the strength of intermolecular forces and some persistence is required in order to isolate derivatives of 2 which do not form 7T —7r dimers in the solid state. A survey of the monomeric derivatives has been published recently.26 Since the spin density distribution in 2 is rather insensitive to chemical tuning, approaches to inhibit dimerisation rely exclusively on structural modifications, which affect the nature of the intermolecular forces. Inclusion of sterically demanding groups, such as 13, 14 and 15 has proved partially successful (in the case of the diradical 14 one ring is involved in formation of a dimer, while the other retains its open shell character). 

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