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And drug discovery

Kubinyi H 1995. The Quantitative Analysis of Structure-Activity Relationships. In Wolff M E (Editor) Burger s Medicinal Chemistry and Drug Discovery. 5th Edition, Volume 1. New York, John Wiley Sons, pp. 497-571. [Pg.735]

A Polmski, RD Eemstem, S Shi, A Kuki. LiBrain Software for automated design of exploratory and targeted combinatorial libraries. In IM Chaiken, KD Janda, eds. Molecular Diversity and Combinatorial Chemistry Libraries and Drug Discovery. ACS Conf Proc Ser. Washington, DC Am Chem Soc, 1996, pp 219-232. [Pg.369]

Moore JT, Collins JL, Pearce KH (2006) The nuclear receptor superfamily and drug discovery. Chem Med Chem 1 504-523... [Pg.1117]

Milosevich SAF, Boyd, DB. Supercomputing and drug discovery research. Per-spect Drug Discovery Design 1993 1 345-58. [Pg.48]

Davies K. Using pharmacophore diversity to select molecules to test from commercial catalogues. In Chaiken IM and Janda KD, editors. Molecular diversity and combinatorial chemistry. Libraries and drug discovery. Washington DC American Chemical Society, 1996 309-16. [Pg.207]

Bredel M, Jacoby E. Chemogenomics An emerging strategy for rapid target and drug discovery. Nat Rev Genet 2004 5 262-75. [Pg.372]

Congreve M, Murray CW, Blundell TL. Structural biology and drug discovery. Drug Discov Today 2005 13 895-907. [Pg.415]

Muegge I, Enyedy I. Docking and scoring. In Tollenaere J, de Winter H, Langenaeker W, Bultinck P, editors. Computational medicinal chemistry and drug discovery. New York Marcel Dekker. 2004. p. 405-36. [Pg.416]

Bhalay G, Dunstan A. Chemokine Receptors and Drug Discovery—SMR meeting. 11 March 2004, Horsham, UK. IDrugs 2004 7(5) 441-443. [Pg.191]

Although, MediChem is a biosecurity products manufacturer, its biotechnology-based R D capabilities are worth mentioning here. The attended markets include Medical, Laboratory, Veterinary, and Environmental sectors. Medicinal chemistry services and drug discovery form the basis of the company, though their capabilities might be applied in a broader range of sectors. These capabilities comprise the areas of Proteomics, Combinatorial and Computational Chemistry, Medicinal Chemistry, Enzymes, Process Development, Analytical and Separations Chemistry, Chemical Synthesis and Scale Up. [Pg.271]

Isolation and characterization of new indole alkaloids remains a fruitful avenue for the discovery of agents with the potential for biomedical application. The virtues of this age-old process, in light of advances in combinatorial chemistry, were brought to the community as part of the 231 ACS National Meeting symposium, Modern Natural Products Chemistry and Drug Discovery <06ORGN467>. [Pg.160]

Searls, D. 2000. Using bioinformatics in gene and drug discovery. Drug Discovery Today 5(4), 135-143. [Pg.104]

G P. Politzer, J. S. Murray, in Computational Medicinal Chemistry and Drug Discovery, J. P. PoLLENAERE, P. BuLTINCK, H. DeWinter, W. Langenaeker (eds), Marcel Dekker, New York, 2002, in press. [Pg.252]

Online LC-MS is a good solution for separation, identification, and quantification because it permits the confirmation of polar and nonvolatile compounds without need for derivatization.4 The use of LC-MS for biological sample detection and data analysis has grown rapidly during the past few years. Many reliable and easy to use LC-MS systems are commercially available and have been adapted for solving analytical problems by scientists in proteomics research, metabolic study, complex natural product separation and characterization, and drug discovery. [Pg.356]

B. P. Imbimbo and F. Speroni, in Burger s Medicinal Chemisty and Drug Discovery (ed. D. J. Abraham), 6th edition, John Wiley Sons, Inc, Hoboken, 2005, p. 1. [Pg.44]

Yan Q (2008) The integration of personalized and systems medicine bioinformatics support for pharmacogenomics and drug discovery. Methods Mol Biol 448 1-19... [Pg.128]

Biological Profiling/Fingerprints and Drug Discovery Applications... [Pg.23]

J. E. Bailey, Lessons from metabolic engineering for functional genomics and drug discovery. Nat. Biotechnol. 17, 616 618 (1999). [Pg.246]

Achyuthan KE, Bergstedt TS, Chen L, Jones RM, Kumaraswamy S, Kushon SA, Ley KD, Lu L, McBranch D, Mukundan H, Rininsland F, Sh X, Xia W, Whitten DG (2005) Fluorescence superquenching of conjugated polyelectrolytes applications for biosensing and drug discovery. J Mater Chem 15 2648-2656... [Pg.383]

Besides, High Resolution/Accurate Mass TOF and Q-TOF spectrometers (Figure 4b) allow full detection at low ppb amounts of drugs and their known and unknown metabolites, and they are fully implemented in Life Science applications like Metabolites Identification (MetID), and Drug Discovery. [Pg.56]


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An Overview of the Drug Discovery and Development

An Overview of the Drug Discovery and Development Process

Application of Biotechnologies in Drug Discovery and Development

Application of Organocatalytic Cascade Reactions in Natural Product Synthesis and Drug Discovery

Aqueous Solubility in Drug Discovery Chemistry, DMPK, and Biological Assays

Biological Mass Spectrometry Basics and Drug Discovery Related Approaches

Biotechnology and Drug Discovery

Cancer drugs discovery and development

Chemical biology and drug discovery

Combinatorial synthesis for drug screening and materials discovery

DRUG DISCOVERY TARGETS AND RECEPTORS

Discovery and Development of Drugs

Drug Discovery and Development in the Middle Ages

Drug design and discovery

Drug discovery and development

Drug discovery and toxicology

Drug discovery design and serendipity

Economics of Drug Discovery and Development

Elements of Drug Discovery and Development

Foundation of Current Drug Discovery and

Fragment-Based Drug Discovery: A Practical Approach Edited by Edward R. Zartler and Michael J. Shapiro

Fragment-Based Drug Discovery: A Practical Approach Edited by Edward R. Zartler and Michael J. Shapiro 2008 John Wiley Sons, Ltd. ISBN

Genomics, Proteomics and Drug Discovery

High-Throughput Screening and Drug Discovery

History of Drug Discovery and Development

Identification in Drug Discovery Kathleen A. Cox, Nigel Clarke, and iane Rindgen

Incorporation of Genomics and DNA-templated Synthesis into Drug Discovery

LC-MS in drug discovery and development

Likeness and Analogue-Based Drug Discovery

Molecular Imaging for Drug Discovery and Development

Organic Synthesis in Drug Discovery and Development

Past and present contributions to drug discovery

Permeability - Measurement and Prediction in Drug Discovery

Pharmacokinetics in Drug Discovery and Development

Pharmacophore and Drug Discovery

Pre-clinical drug discovery and

Pre-clinical drug discovery and development

Predicting Selectivity and Druggability in Drug Discovery

Primacy of the Pharmaceutical Industry in Drug Discovery and Development

Protein Crystallography and Drug Discovery

The Expert System for Metabolism Prediction in Drug Design and Discovery

The Importance of Natural Products in Drug Discovery and Development

The Polar Surface Area and Its Application in Drug Discovery

The impact of genomics and related technologies upon drug discovery

Tools and Their Integration in the Drug Discovery Process

Trends in Drug Discovery and Development

Use of Transition Metal-Catalyzed Cascade Reactions in Natural Product Synthesis and Drug Discovery

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