Application-Based Selection

Wilbur, D., Scott, C., Ming-Kuan, P., Pradip, M., and Hamlin, D.K. (2000) Biotin reagents for antibody pretargeting. 4. Selection of biotin conjugates for in vivo application based on their dissociation rate. Bioconj. Chem. 11, 569-583. 

Unlike the FDA, the EMEA itself does not directly undertake appraisals of drug dossiers submitted to support marketing authorization applications under the centralized procedure. Instead (as discussed in detail below), they forward the dossier to selected national EU regulatory bodies, who undertake the appraisal, and the EMEA makes a recommendation to approve (or not) the application based upon the national body s report. The overall role of the EMEA is thus to coordinate and manage the new system. The EMEA s annual budget is of the order of 120 million. The key objectives of the EMEA may be summarized as ... 

This, of course, is a very important part of the program. We are developing it on an as-needed basis in response to feedback from users. In particular, we still have not implemented a complete explanation facility. The user interface currently provides online help and a menu based selection of valid responses whenever applicable. 

As with any process analytical application, instrument selection is based on the required analytical merits (sensitivity, dynamic range, precision and accuracy, etc.), process and enviromnental conditions, integration complexities (mechanical and controls automation) and operational and maintenance requirements. Because of the wide disparity in analytical performance and functionalities among photometric and spectroscopic LIE process instruments, selection should be carefully weighed on the basis of the technical problem, instrumental cost, implementation complexities, ease of use, conunercial and legacy maturity, level of vendor support and cost of ownership. 

Appointments of rapporteur and co-rapporteur were made on the basis of two criteria first, the preferences expressed by the applicant, and second, the preferences of CHMP members based on their expertise. The CHMP will no longer take into account preferences expressed by applicants in selecting rapporteurs. A member of staff of the Pre-authorisation Evaluation of Medicines for Human Use Unit of the EMEA is officially... 

Carr SA, Annan RS, Huddleston MJ. Mapping posttranslational modifications of proteins by MS-based selective detection Application to phosphoproteomics. In Burlingame AL, ed.. Mass Spectrometry Modified Proteins and Glycoconjugates, Vol. 405, New York Academic Press, 2005, 82-115. 

Different catalysts bring about different types of isomerization of hydrocarbons. Acids are the best known and most important catalysts bringing about isomerization through a carbocationic process. Brpnsted and Lewis acids, acidic solids, and superacids are used in different applications. Base-catalyzed isomerizations of hydrocarbons are less frequent, with mainly alkenes undergoing such transformations. Acetylenes and allenes are also interconverted in base-catalyzed reactions. Metals with dehydrogenating-hydrogenating activity usually supported on oxides are also used to bring about isomerizations. Zeolites with shape-selective characteristics... 

Classical Friedel-Crafts catalysts such as BF3 etherate or Bronstedt acids, which are applied in stoichiometric amounts or even in excess, still have their value, because they are relatively inexpensive yet powerful catalysts for C-H transformation at arenes and, most importantly, they are often successful when modern catalysts fail. Gold(III) chloride, at less than 1 %, has impressive reactivity under very moderate reaction conditions and its selectivity is exceptionally good. Friedel-Crafts type reactions with this catalyst are, however, restricted to very electron-rich arenes. Further studies should concentrate on increasing the electrophilicity of gold catalysts. New catalysts have emerged, for instance based on ruthenium and rhenium, which promise broad applicability based on alternative mechanisms. Catalysts based on rare earth metals are discussed in the next chapter. 

Virtually every step within the generalized scheme (Figure 1) for pesticide atmospheric entry, behavior, and fate has been demonstrated with at least a few examples. Developments in sampling-analysis methodology, and its application to selected field treatments, have provided the data upon which present knowledge is primarily based. The best data probably lie in... 

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