Appetite suppressant, phenylpropanolamine

Lee KY, Beilin LJ, Vandongen R. Severe hypertension after ingestion of an appetite suppressant (phenylpropanolamine) with indomethacin. Lancet 1979 1(8126) 1110-11. 

This equation describes the steady-state, or zero-order, release of the dmg. When the dmg completely dissolves, its concentration within the system begins to dilute, and the release rate foUows a parabohc decline with time (102). Acutrim (ALZA Corp.), dehvering phenylpropanolamine hydrochloride [154-41 -6] for appetite suppression, is an example of an elementary osmotic pump. 

Acutrim 16 Hour Steady Control Tablets. Acuttim is an appetite suppressant diet aid available without a prescription and marketed by CIBA Consumer Pharmaceuticals. The active ingredient is phenylpropanolamine hydrochloride [154-41 -6] a sympathomimetic amine (see Antiobesity drugs). Acutrim dehvers its dosage at a precisely controlled rate for up to 16 hours. This is achieved through the OROS technology. 

Phenylpropanolamine was a common component in over-the-counter appetite suppressants. It was removed from the market because its use was associated with hemorrhagic strokes in young women. The mechanism of this potential adverse effect is unknown, but the drug can increase blood pressure in patients with impaired autonomic reflexes. 

Older drugs still available in some countries include phenylpropanolamine, benzphetamine, amphetamine, methamphetamine, phentermine, diethylpropion, mazindol, and phendimetrazine. These drugs are all amphetamine mimics and are central nervous system appetite suppressants they are generally helpful only during the first few weeks of therapy. Their toxicity is significant and includes hypertension (with a risk of cerebral hemorrhage) and addiction liability. 

Call it the original diet pill. The introduction of the OTC appetite suppressant Dexatrim in 1976 marked the beginning of an era in the history of dieting trends. The pill s main ingredient was phenylpropanolamine (PPA). This substance works by affecting the hypothalamus—the part... 

Severe systemic hypertension developed in a patient who took indometacin shortly after taking an appetite suppressant (Trimolets) containing phenylpropanolamine (20). The hypertension was attributed to inhibition of prostaglandin synthesis by indometacin, which exacerbated the sympathomimetic effects of phenylpropanolamine. However, in 14 young, healthy, normotensive women who were randomized double-blind to modified-release phenylpropanolamine 75 mg/day or placebo for 4 days, modified-release indometacin 75 mg bd had no significant effect on mean systolic or diastolic blood pressures (21). 

Molindone (50 to 75 mg/day) is indicated in the management of the manifestations of psychotic disorders. Molindone is strncturally nnrelated to the phenothiazines, butyrophenones, or thioxanthenes, but it resembles the piperazine phenothiazines in its clinical action. It causes sedation, possesses anticholinergic properties and, similar to flnphenazine, produces movement disorders. Molindone is metabolized, and the metabolites are excreted in the nrine. It lowers the seizure threshold and may cause seizures in patients with epilepsy and other seizure disorders. Concomitant nse with sympathomimetics, including epinephrine, phenylephrine, phenylpropanolamine, and ephedrine (often fonnd in nasal sprays), or appetite suppressants may decrease their stimulatory and pressor effects. Becanse of its alpha-blocking potential, molindone may canse epinephrine reversal—a hypotensive response to epinephrine. 

Concomitant use of perphenazine with sympathomimet-ics, including epinephrine, phenylephrine, phenylpropanolamine, and ephedrine (often found in nasal sprays), and with appetite suppressants may decrease their stimulatory and pressor effects. Phenothiazines can cause epinephrine reversal and a hypotensive response when epinephrine is used for its pressor effects. 

Tan, H.S. Salvador, G.C. Assay of mixtures of phenylpropanolamine hydrochloride and caffeine in appetite suppressant formulations by high-performance liquid chromatography. J.Chromatogr., 1983, 261, 111-116... 

A woman who had been taking phenylpropanolamine 85 mg daily for several months as an appetite suppressant, developed a severe bifrontal headache within 15 minutes of taking indometacin 25 mg. Thirty minutes later her systolic blood pressure was 210 mmHg and her diastolic blood pressure was unrecordable. A later study in this patient confirmed that neither drug on its own caused this response, but when they were taken together the blood pressure rose to a maximum of 200/150 mmHg within about 30 minutes of taking the indometacin, and was associated with bradycardia. The blood pressure was rapidly reduced by phentolamine. ... 

Uses Intermediate for Friedel-Crafts synthesis stabilizer for chlorinated solvents fuel additive specialty solvent for coating, adhesive, and Ink formulations solvent for cellulose esters, vinyl, alkyd, other resins and waxes propellant raw material for pharmaceutical synthesis (ot-me-thyldopa, a hypertensive drug, phenylpropanolamine, in bronchial decongestants and appetite suppressants)... 

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