Antitumor gold complexes

Table 6.4 Cytotoxcitiy and antitumor activity of selected gold complexes on B16 Melanocytes and P388 leukocyte. Adapted from Shaw [17].

B. Brown, A. R. Khokhar, M. P. Hacker, J. J. MacCormack, and R. A. Newman, Synthesis and Biological Studies of a New Class of Antitumor Platinum Complexes, in S. J. Lippard, ed.. Platinum, Gold, and Other Metal Chemotherapeutic Agents, American Chemical Society, Washington, DC, 1983, pp. 265-277. 

Trivalent gold complexes were potentially attractive as anticancer agents because of their cytotoxic effects on established human tumor cell lines. All tested Au+ complexes substantially retained their antitumor potency against platinum-resistant tumor cell lines for leukemia and ovarian cancer. Cytotoxicity of these compounds in vitro is attributed to binding with DNA and modification and subsequent impairment of replication and transcription processes. The paucity of data on Au+ complexes probably derives from their high redox potential and relatively poor stability, which makes their use problematical under physiological conditions. 

Gold Complexes as Antitumor Agents Luigi Messori and Giordana Marcon... 

Moustatih, A., and Garnier-Suillerot, A. (1989) Bifunctional antitumor compounds synthesis and characterization of a gold(III)-streptonigrin complex with thiol-modulating properties. Journal of Medicinal Chemistry, 32, 1426. 

Messori, L, Abbate, F., Marcon, G., Orioli, P., Fontani, M., Mini, E., Mazzei, T., Carotti, S., O Connell, T. and Zanello, P. (2000) Gold(lll) complexes as potential antitumor agents solution chemistry and cytotoxic properties of some selected gold(III) compounds. Journal of Medicinal Chemistry, 43, 3541. 

Antitumor properties of some 2-[(dimethylamino)methyl]phenyl-gold(lll) complexes./oumoi of Medicinal Chemistry, 39, 5208. 

As auranofin demonstrates both anti-arthritic and antitumor effects, many analogs differing in the thiolate and the phosphine residues have been characterized [18, 21, 51-53]. Like auranofin, these complexes are generally linear at the two-coordinate gold center. Di- i-(diethylphosphinoethylthio)digold(I) is a complex that... 

Shaw, C.F. Ill, Beery, A. and Stocco, G.C. (1986) Antitumor activity of two binudear gold(I) complexes with bridging dithiolate ligands. Inorganica Chimica Acta, 123, 213-216. 

Mirabelli, C.K., Johnson, R.K. and Hdl, D.T. (1986) Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes./oumal of Medicinal Chemistry, 29, 218-223. 

McKeage, M.J., Maharaj, L. and Berners-Price, S.J. (2002) Mechanisms of cytotoxicity and antitumor activity of gold(I) phosphine complexes the possible role of mitochondria. Coordination Chemistry Reviews, 232, 127—135. 

Exploration of new complexes with useful antimicrobial activities has stimulated extensive development of synthetic chemistry of silver(I) complexes. The incorporation of novel ligands can moderate the physical and chemical properties of complexes. For example, the bis(diphosphine)silver(I) complexes (which are analogues of the bis(diphosphine)gold(l) complexes with promising antitumor activity compromised by their antimitochondrial activity) were examined for antitumor and antimicrobial activity by... 

Metallic elements used in medicine include lithium for treating manic depressive illness, platinum complexes such as c/.s-platin (2), which act as antitumor agents by combining with DNA and inhibiting cell division, and gold compounds used to treat arthritis. 

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