Dinuclear platinum complexes

Short nonbonded Si—Si distances have been observed in four membered metallacycles (Scheme 12b) with a Pt, Ir, W, or Nb atom [138-142] in place of one of the oxygen (nitrogen) atoms of 1,3-cyclodisilazanes (1,3-cyclodisilazanes) and in U-silylene-bridged dinuclear platinum complexes (Scheme 12c) [143, 144]. Electron donating occupied orbitals are expected to be on the platinum atoms like lone pair orbitals on the oxygen atoms in cyclodisiloxanes. 

The first-generation dendron 29 was grown up to the second- and third-generation dendrons 33 and 34 by the successive reaction with dinuclear platinum complex 32 followed by treatment with TBAF for desilylation (Scheme 11). Reactions of the second- and third-generation dendrons 33 and 34 with the core 30 gave the second- and third-generation dendrimers, respectively. Although... 

An A-frame dinuclear platinum complex in the form of [Pt2(/u.-dppm)2(/x-CCR)(CCR)2]+ (15a) displays more red-shift lower energy bands than the mononuclear complexes. Such a change is attributed to a metal-metal bond to ligand charge-transfer (MMLCT) [da pa/n ( 5 )] transition... 

Kalayda GV, Jansen BAJ, Molenaar C, Wielaard P, Tanke HJ, Reedijk J. Dinuclear platinum complexes with N,N -bis(amino-alkyl)-l,4-diaminoanthraquinones as linking ligands. Part II. Cellular processing in A2780 cisplatin-resistant human ovarian... 

Zou, Y., Van Houten, B., and Farrell, N. (1994) Sequence specificity of DNA-DNA interstrand cross-link formation by cisplatin and dinuclear platinum complexes. Biochemistry, 33, 5404-5410. 

The trans isomer of a dinuclear platinum complex can form intrastrand DNA crosslinks, which do not distort the molecule s shape but disrupt its function. Here the two chloride ligands of the complex ion are replaced by the N atoms in the five-membered ring of the guanines on two different strands. The rodlike structure represents the bases held together by hydrogen bonds. 

Such aquo complexes react with triphenylphosphine yielding the corresponding phosphino compound. It is noteworthy that while the dinuclear platinum complexes do not react with water to produce the hydroxo compound and the formation of this hydroxo compound requires the refluxing of the halide complexes with KOH or NBU4OH for 24 hours, the silver derivatives decompose in solution with NBU4OH and react with water under mild conditions to form the hydroxo complex. Similarly, while the dinuclear platinum complexes do not react, for instance, with tht to cleave the bridging Pt(y(i-X)Pt system, the aquo silver compound reacts with tetrahy-... 

Fig. 23 1 -D MMX complexes and a dinuclear platinum complex bearing dithiocarboxylato ligands...

Scheme 7 Olefin dioxy-functionalization with a dinuclear platinum complex...

The hydrolysis profile of the bifunctional dinuclear platinum complex [ trans-PtCl( 5NH3)2 2(jr - NH2(CH2)6 NH2)f+ (l,l/t,t( = 6), 10, the prototype of a novel class of potential antitumor complexes, has recently been studied by using [ H, N] HSQC NMR spectroscopy [62]. The process of the hydrolysis is sketched in Scheme 5.2. An interesting finding is that the position of the... 

A tetradentate phosphine ligand has been prepared and employed as the chelating ligand in dinuclear platinum complexes (Equation (33)). PtClMe(cod) reacts with the phosphine in the presence of T1PF6 to form the dinuclear complex with a bridging chloro ligand 148. 

Transmetallation of l,T-bis(trimethylstannyl)ruthenocene 228 with PtC cod) has been employed for the preparation of a dinuclear platinum complex with a bridging ruthenocene-diyl ligand (229, Equation (62)). " ... 

Fig. 5.2. Extreme arrangements for the interaction of a dinuclear platinum complex with DNA showing possible inter- (a and b) and intrastrand (c) links. From Reference 31.

Additional products synthesized by Reedijk are so-called dinuclear platinum complexes. In other work, such complexes have been found to offer high in vivo activity in both ciplatin and resistant tumors. ... 

Braunschweig H, Bertermann R, Damme A, KupferT. A dinuclear platinum complex feamring the diboran(4)-l,2-diyl ligand in a Jl2-hridging coordination mode. Chem Commun. 2013 49 2439-2441. 

Mochida and coworkers studied the oxidative addition and rearrangement chemistry of hydrogenated di- and trisilanes with Pt(0) complexes. Dinuclear platinum complexes with silylene or silanylene bridges were frequently formed in the course of these reactions (Scheme 37) [435-438]. 

---