Antituberculous activity

Lall N, Hussein AA, Meyer JJM. (2006) Antiviral and antituberculous activity of Helichrysum melanacme constituents. Eitoterapia 77 230-232. 

Grange, ]. M., and R. W. Davey. Detection of antituberculous activity in plant extracts. J Appl Bacteriol 1990 68(6) 587-591. 

Amicetin, the first nucleoside in a series of structurally related, antibiotic substances isolated from Streptomyces cultures, was shown to possess antituberculous activity.9 Proof of the main structural features of this rather complex nucleoside (XXXIV) represents an interesting example of the use of degradative procedures coupled with periodate oxidations, spectrophotometric methods, and potentiometric titrations163-167 (see XXXIV-XL). 

Willand N, Dirie B, Carette X et al (2009) Synthetic EthR inhibitors boost antituberculous activity of ethionamide. Nat Med 15 537-544... 

One of the reaction products of (210) and hydroxylamine is the 4,5-dihydroanthranil (211), which shows antituberculous activity.343... 

Diterpenoids are the most important compounds responsible of the biological activities found in numerous Salvia species. Antituberculous effects have been established for S. blepharochlyna [5], S. multicaulis also reported for it s antifungic effect [6] and S. prionitis which possess antiphlogistic and antibacterial properties [7,8] beside its antituberculous activity. 

Ulubelen, A., Toppu, G. 1997. Norditerpenoids and diterpenoids from Salvia multicaulis with antituberculous activity. J. Nat. Prods. 60 1275-1280. 

Davies, G. E., Driver, G. W. The antituberculous activity of ethyl thi-olesters with particular reference to diethyl dithioh sophtalate. Br. J. Pharmacol. 1957,12, 434-437. 

The product had already been synthesized by Kushner et al. (1952), and Smith (V.K.) and Kushner (1954) and Shindo (I960), in relation with a study on the antituberculous activity of pyrazina-mide, an aza-analog of nicotinamide (Cote et al., 1953). A preparation procedure was also described by Wolt (1975a). The synthesis is usually performed by dehydration of the commercially available pyrazinamide into 2-cyanopyrazine followed by a Grignard reaction (Ohloff et al., 1985). 

Para-aminosahcylate, an aminobenzoic acid analog with antituberculant activity (12 to 15 g p.o. daily), is indicated as adjunctive treatment of tuberculosis. 

In a recent study, with S. multicaulis, four of the new compounds (29-32) showed structural resemblence to tanshinone-type compounds. Therefore, they and the other new compounds (33-34 ) isolated from the same plant, were tested against bacterial strains (Table 28). All the compounds from this plant were also tested in Mycobacterium tuberculosis H37Rv test system. Their antituberculous activity was established according to broth microdilution method . When the MIC results were... 

Rist, N., Grumbach, F. and Liberman, D. (1959) Experiments on the antituberculous activity of alpha-ethyl-thioisonicotinainide. Am. Rev. Tuberc. 79 1-5. 

Chirata xanthones (swertianin, 1,3,7,8-tetra-hydroxyxanthone, and 1,8-dihydroxy-3,7-dimethoxyxanthone) are claimed to have antituberculous activities. Amarogentin has shown in vitro hepatoprotective activity against carbon tetrachloride toxicity. Swerchirin has shown antimalarial activity in vivo ... 

Lipimova G, Nosova E, Kravchenko M, Sidorova L, Tsoi E, Mokrushina G, Chasovskikh O, Charushin V (2004) Fluorinated quinolones possessing antituberculous activity. Pharm Chem J 38 597-601... 

The rest substances appeared to be inactive. For compound X was studied antituberculous activity in vitro towards microorganism [10] was revealed a weak activity against micobacteria Mycobaqterium tuberculosis H 37, Mycobaqterium tuberculosis academia and Mycobaqterium tuberculosis bovis 8. Minimal inhibitory concentration (MIC) in mkg/ml was consequently 23,153 and 23. 

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