Antirheumatic agents

Podophyllotoxin (Fig. 4), a non-alkaloid toxin lignan, is a laxative, anti-tumor and antirheumatic agent. Cell cultures of Linum flavum were shown to be able to convert deoxypodophyllotoxin, a lignan isolated from Anthriscus sylvestris, into podophyllotoxin. ... 

Diuretic and urinary disinfectant The pharmaceutical effects mentioned in note / may cause complications. Antirheumatic agent The pharmaceutical effects mentioned in note / may cause comphcations. ... 

Etanercept therapy should not be initiated in patients with active infection. If an infection develops in a person taking etanercept, he or she should be closely monitored. If a serious infection or sepsis occurs, the drug should be discontinued. Etanercept should be used with caution in individuals who have conditions predisposing them to serious infection (e.g., uncontrolled diabetes, hematological abnormalities). Data on drug interactions are limited. Live virus vaccines are contraindicated because of the potential for secondary transmission of the infection by the vaccine. Myelo-suppressive antirheumatic agents have been associated with pancytopenia in some patients treated with etanercept. 

Anakinra (Kineret) is the first antirheumatic agent that acts by blocking the action of IL-1. This drug was recently approved for the treatment of moderately to severely active rheumatoid arthritis in adults who have not responded to therapy with one or more DMARDs. Anakinra may be used alone or in combination with DMARDs other than the TNF antagonists. Clinical trials have shown anakinra to be more effective than placebo, either alone or in conjunction with methotrexate. 

Datura alba Nees. D. fastuosa L. var. alba Clark D. innoxia Mill. D. metel L. D. stramonium L. D. talula L. Man Tu Luo (Jimsonweed) (leaf, seed, flower) Scopolamine, hyoscyamine, daturodiol, daturolone, hyoscine.33-144 450 This herb is toxic. Spasmolytic, analgesic, antiasthmatic, antirheumatic agent. A general anesthetic for major operations. 

Rainer, G.f Kruger, U., Klemm, K.. [Synthesis and physico-chemical properties of lonazolac-Ca, a new antiphlogistic/antirheumatic agent], Arzneim.-Forsch./Drug Res. 1981, 31, 649-655. 

Schonhofer PS. Interaktionen antirheumatisch wirksamer Substanzen. [Interactions of antirheumatic agents.] Internist (Berl) 1979 20(9) 433-8. 

It is highly effective in terminating acute vivax and falciparum malaria. It is also valuable in the treatment of intraintestinal amebiasis and some cases of giardiasis (1). Chloroquine also produce symptomatic improvement in Barbesia infections. It can be used as an antirheumatic agent (23). 

Antirheumatic agents, [l,2,4)triazolo-[l,5-a]pyrimidines, 57, 126 Antitumor agents... 

UDCA -H sulindac The additional administration of sulindac, a non-steroidal antirheumatic agent (100-300 mg/day), showed an improvement in laboratory parameters - probably due to its choleretic effect. (179)... 

Miles SM, Bird HA. Clinical signifiance of drug interactions with antirheumatic agents. Chn Immunother 1996 5 205-13. 

Ritschard T, FUippini L. Nebenwirkungen nichtsteroidaler Antirheumatika auf den unteren Intestinaltrakt. [Side effects of non-steroidal antirheumatic agents on the lower intestinal tract.] Dtsch Med Wochenschr 1986 111(41) 1561. ... 

C12H9F3N202 Enzyme inhibitor Immunosuppressive agent Antirheumatic agent Oral tablet 75706-12-6 Sept. 1998/ Sanofi Aventis US Aptoex Inc. Barr Kali Labs SandozA Teva Products... 

Epoxyquinomicin B (583), an antirheumatic agent, was synthesized in 22% overall yield in 8 steps starting from commercially available 3-hydroxy -nitrobenzaldehyde (584), which was easily converted to the amidophenol 585. Fremy s salt oxidation of 585 in Et0Ac-H20 was carried out at room temperature overnight to afford selectively in 82% yield the desired p-benzoquinone (586). This was treated with H202-NaHC03 in MeOH to yield the target molecule 583 (Scheme 109) . 

Leflunomide is an antirheumatic agent. It is an isoxazole immunomodulatory agent that inhibits dihydro-orotate dehydrogenase and has antiproliferative and antiinflammatory activity. It is indicated in the treatment of active rheumatoid arthritis (RA) to reduce signs and symptoms and to retard structural damage. 

Steroidal and some non-steroidal antirheumatic agents are capable of suppressing or reducing these inflammatory reactions . 

On the assumption that 2,3-dihydroxybenzoic acid (pyrocatechoic acid, V, = R2 = H) is formed in humans after salicylate ingestion and that it may be the antirheumatic agent, clinical studies were carried out with this compound in rheumatic fever in which it appears to be superior to sodium salicylate although of lower toxicity, but ineffective in rheumatoid arthritis i > i. Other workers found the drug to be twice as active as salicylate in rheumatic fever and less toxic in therapeutic doses . Trials with diacetyl-pyrocatechol-3-carboxylic acid (Movirene, V, R = R = COMe) in various rheumatic conditions were also favourable > . 

A further distinction can be made between rapidly acting antirheumatic agents which uncouple and slow-acting ones, such as chloroquine and the corticosteroids which, though not uncouplers, inhibit oxidative processes and may therefore achieve, by a different means, the same interference with anabolic processes essential for connective tissue function. 

Sideritis mugronensis an endemic plant of eastern Spain and is used in folk medicine as anti-inflammatory and antirheumatic agent. The active principle was found to be hypolaetin 8-glucoside (140) [58]. 

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