Antirheumatic

Table 2. Traditional Antirheumatic Drugs Having Immunological Activity ...

Fig. 2. Pyrazole-derived pharmaceuticals (a) butaglyon [2603-23-8] an antidiabetic (b) dazopride [70181 -03-2] an antiemetic (c) feclobuzo [23111-34 ] an antiinflammatory (d) kebuzone [833-34-9], an antirheumatic (e) muzolimin [55294-15-0], a diuretic (f) phenazobz [20610-63-3], an antiasthmatic (g) selenofob [39102-63-1], an antibiotic (h) sulfamazo [65761-24-2], an antiseptic and (i) sulfinpyrazone [57-96-5], an antigout preparation (50).

Medicinals. Many esters are used as pharmaceuticals (105,106). Of these, benzocaine, ethyl 4-aminobenzoate [94-09-7] is a topical anesthetic. Phenyl saHcylate [118-55-8] (1) has antipyretic, antirheumatic, and antiparasitic properties. 

Oxyphenbutazone (712), y-hydroxyphenylbutazone and kebuzone (715) are metabolites of phenylbutazone in liver. The first cited is an equally potent antiinflammatory agent but slightly less toxic. Compounds (711) and (712) are rarely used as analgesics and antipyretics because of their toxicities. The first one is used in therapy of rheumatoid disorders characterized by a lack of detectable antiglobulin and antinuclear antibodies in the serum. The y-hydroxyphenylbutazone has marked uricosuric activity but little antirheumatic effect. Kebuzone (715) is an antiinflammatory agent still widely used in Europe. 

From the various modifications that have been made on the phenylbutazone structure in order to increase activity and reduce toxicity it has been found that the activity persists when methyl, chloro, hydroxy or nitro groups are introduced into the para position of one or both benzene rings (see oxyphenbutazone (712) as an example). Mofebutazone (714) has also been used in Europe for several years as an antirheumatic drug. 

Therapeutic Function Analgesic, antipyretic, antirheumatic Chemical Name 2-(Acetyloxy)benzoic acid calcium salt Common Name Calcium aspirin calcium acetylsallcylate... 

The antiinflammatory drugs include the nonsteroidal antiinflammatory drugs (NSABDs —> analgesics) —> cyclooxigenases), the disease modifying antirheumatic... 

The miscellaneous drugp are used to treat a variety of musculoskeletal disorders. Ffenicillamine, methotrexate (MTX), and hydroxychloroquine are used to treat rheumatoid arthritis in patients who have had an insufficient therapeutic response to or are intolerant of other antirheumatic drugp such as the sailcylates and NSAIDs. The Summary Drug Table Drug s Used to Tream Musculoskeletal Disorders provides additional information about these and other drug s. One compound, hylan G-F 20, listed in the Summary Drug Table is not used for rheumatoid arthritis, but rather, for osteoarthritis knee pain. It is a viscous, elastic... 

ATC M01AB05 M02AA15 S01BC03 Use anti-inflammatory, antirheumatic... 

Use antidote (heavy metal poisonings), antirheumatic (PCA and Morbus Wilson)... 

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