Adverse drug reactions antirheumatic drugs

Benoral benorylate. benorilate benorylate. benorylate [ban] (benorilate [inn] paracetamol acetylsallcylate BenoraP ) is an aspirin-paracetamol ester, and these two pharmacologically active constituents are released systemically at different rates. It has cyclooxygenase inhibitor, nsaid analgesic, antiinflammatory and antirheumatic activity. It is used orally, particularly to treat the pain of rheumatic disease and other musculoskeletal disorders, as well as to treat fever, benoxaprofen [ban, inn, usan] (Opren ) is one of the propionic acid series of CYCLOOXYGENASE INHIBITORS with nsaid ANALGESIC. ANTIINFLAMMATORY and ANTIPYRETIC activity also effective for psoriasis. It was withdrawn due to adverse drug reactions. 

Cuthbert MF. Adverse reactions to non-steroidal antirheumatic drugs. Curr Med Res Opin 1974 2(9) 600-10. 

When these drugs are administered in doses that have similar antirheumatic strengths, the general incidence of adverse reactions with prednisone and prednisolone is about the same as that with hydrocortisone. The compounds differ, however, in their tendencies to induce individual side effects. The incidence and degree of salt and water retention and blood pressure elevation are less with the A -corticoids. Conversely, these analogues are more likely to promote digestive complaints, peptic ulcer, vasomotor symptoms, and cutaneous ecchymosis. 

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