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Leflunomide Antirheumatics

Among the isoxazoles, many biologically active compounds are found. Some of them are important as drugs or biocides, e.g. the long-acting sulfonamide sulfamethoxazole 10, the anti-inflammatory isoxi-cam 11, the antiarthritic and antirheumatic leflunomide 12 and the fungicide 3-hydroxy-5-methylisoxazole. [Pg.142]

Leflunomide (Arava) is a relative newcomer to the antirheumatic drug arsenal. This drug helps decrease pain and inflammation in rheumatoid joint disease, and leflunomide has been shown to slow the formation of bone erosions in arthritic joints.19 Leflunomide is also fairly well tolerated by most patients and may produce beneficial effects fairly soon (1 month) after beginning treatment.57,105 This drug is therefore a po-... [Pg.225]

Leflunomide (Arava) is an oral immunomodulatory agent, which is considered effective for the treatment of RA. Leflunomide is a disease-modifying antirheumatic drug that is approved for treatment of RA (Bartlett et al., 1991 Strand et al, 1999 Smolen et al. 1999 Emery et al. 2000 Breedveld and Dayer, 2000). [Pg.189]

However, the rate of adverse effects associated with leflunomide was significantly lower than with methotrexate and other disease-modifying antirheumatic drugs (DMARDs) in an analysis of 40 594 patients with rheumatoid arthritis (8,51). The incidences of adverse events per 1000 patient-years were as follows ... [Pg.2016]

Cannon GW, Holden WL, Juhaeri J, Dai W, Scarazzini L, Stang P. Adverse events with disease modifying antirheumatic drugs (DMARD) a cohort study of leflunomide compared with other DMARD. J Rheumatol 2004 31(10) 1906-11. [Pg.2022]

Leflunomide is an antirheumatic agent. It is an isoxazole immunomodulatory agent that inhibits dihydro-orotate dehydrogenase and has antiproliferative and antiinflammatory activity. It is indicated in the treatment of active rheumatoid arthritis (RA) to reduce signs and symptoms and to retard structural damage. [Pg.382]

Slow-acting antirheumatic drugs Methotrexate Hydroxychloroquine, sulfasalazine Infliximab, etanercept, leflunomide, penicillamine, gold... [Pg.327]

The client diagnosed with rheumatoid arthritis is taking the disease-modifying antirheumatic drug (DMARD) leflunomide (Arava). Which comment by the client would warrant intervention by the nurse ... [Pg.245]


See other pages where Leflunomide Antirheumatics is mentioned: [Pg.34]    [Pg.202]    [Pg.292]    [Pg.388]    [Pg.2271]   
See also in sourсe #XX -- [ Pg.245 ]

See also in sourсe #XX -- [ Pg.1065 ]




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Antirheumatic

Leflunomide

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