Action of Selected Antipyretic-Analgesics

The mechanism of action of certain selected antipyretic-analgesics included in this chapter (section 10.2) are discussed in the sections that follows  

It causes antipyresis by exerting its action on the hypothalamic heat-regulating centre, and analgesia by enhancing the pain threshold profile appreciably. It is found to lack the anti-inflammatory 

It is considered to be relatively safer drug in the doses recommended for analgesia. Hence, it may be administered in intermittent periods, not exceeding a few days in any circumstances. The analgesic effect is quite selective for pharmacological action(s) ranging from simple headache to the pain associated with many muscles and joints. 

It is considered to be one of the choicest drug specifically for salicylate medieation and is usually administered with either sodium bicarbonate to minimise effeetively the gastric distress or as enteric-coated dosage forms. However, the usage of NaHCOj is not advisable as it is found to retard the plasma levels of salicylate and enhances the elimination of free salicylate in the urine. 

The ester is usually hydrolyzed following its immediate systemie absorption. It is believed to afford much less gastric irritation and discomfort in comparison to aspirin , by virtue of the fact that the drug is virtually insoluble in the stomach and, therefore, never gets absorbed imless and imtil it happens to gain its access into the small-intestine. It is found to be as effective as aspirin and definitely possess fewer side effects. 

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