Antiplatelet aggregation effect

However, while an adequate platelet number appears to be a necessary requirement for metastasis formation, since induction of thrombocytopenia is associated with a decrease in metastases number (Gasic et al., 1968, 1973 Karpatkin et al., 1988), there is considerable controversy regarding the effects of antiplatelet aggregating agents on metastases formation (Karpatkin et al., 1988, 1991). Therefore, a different approach was taken in delineating the mechanism of platelet requirement in tumor metastasis, directing attention to adhesion of tumor cells to activated platelets and platelet adhesive proteins (Karpatkin et al., 1988 Nierodzik et al., 1991,... 

Stilbenoids from the roots of Vitis thunbergii displayed strong antiplatelet activity, such as (-)-viniferal (771), ampelopsin C, miyabenol A and (+)-vitisin C (700) [245]. Marchantinquinone exerted antiplatelet effects by inhibiting phosphoinositide turnover [514]. Antiplatelet aggregation activities have also been reported for piceid [390,515], rhaponticin [515] gigantol, moscatilin, scoparone and scopoletin [92]. 

Progressively higher doses of ASA cause antiplatelet aggregation, analgesia, antipyresis, and antiinflammation. The mechanisms responsible for each of these responses, modes of excretion, effects on the acid-base balance, and side effects are discussed. 

There is also a need to assess the role of the colonic microflora in the overall bioavailability and potential bioactivity of dietary flavonoids. The amoxmt of absorption of colonic metabolites is unclear at this time, and there is growing interest in the potential effects of the phenolic acids and their derivatives as potentially beneficial agents. For example, thehumanintestinalbacteriametabolites of rutin and quercetin, 3,4-dihydroxyphenylacetic acid, and 4-hydroxyl-phenyl-acetic acid have been shown to possess more effective antiplatelet aggregation activity than ratin and quercetin [107]. Furthermore, 2,4,6-trihydroxybenzaldehyde and quercetin were more effective than rutin in their cytotoxicity against tumor cell lines. The effects the phenolics themselves have on the microflora are an emerging field, and it is possible that a flavonoid-induced change in the rich colonic bacterial population may have an influence on the overall health of the individual. 

Other activities reported for ginger include hypoglycentic, antihyperlipi-demic, inununomodulatory, antiplatelet aggregation, androgenic, and antiwrinkling effects. ... 

Adenosine has exhibited antiplatelet aggregation and central inhibitory activities (analgesic, reducing spontaneous motor activity, and prolonging death time induced by caffeine) also has weak muscle relaxant effects (see ganodemta) ... 

Ferulic acid has antiallergic, broad cardiovascular, and hematologic effects (antiplatelet aggregation, antithrombic, etc.) as well as inhibitory effects on lipid peroxidation (see angelica) ... 

Subsequent clinical studies provided additional evidence that GTN exerts antiplatelet activity in vivo and offered insight into the nature of GTN s anti-aggregatory pharmacology. A dose-effect relationship between intravenous GTN and inhibition of platelet aggregation was uncovered in healthy male subjects, in whom plasma... 

Mechanism of Action An antiplatelet and antithrombotic agent that binds to platelet receptorglycoproteinllb/Illa, preventing binding of fibrinogen. Therapeutic Effect inhibits platelet aggregation and thrombus formation. 

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