Colon microflora

KRUL C, HUMBLOT C, PHILIPPE C, VERMEULEN M, VAN NUENEN M, HAVENAAR R and RABOT S (2002) Metabolism of sinigrin (2-propenyl glucosinolate) by the hiunan colonic microflora in a dynamic in vitro large-intestinal model . Carcinogenesis, 23 1009-16. 

Although the above profusion of in vivo studies evidence their health potentialities, the problem of the bioavailabihty of proanthocyanidins supplied by dietary supplementation has still not been completely resolved since unequivocal evidence for absorption is missing so far [11]. However, studies carried out using radio-labelled procyanidins revealed that dimers and trimers may be absorbed by intestinal cells, whereas a recent study demonstrated that procyanidin oligomers are readily adsorbed in rats [55], while it has been shown that colon microflora may be able to degrade proanthocyanidins to low-molecular-weight aromatic compounds [56]. 

Nord CE, Kager L, Philipson A, Stiemstedt G Effect of impipenem/cilastatin on the colonic microflora. Rev Infect Dis 1985 7(suppl 3) S432-S434. 

Nord CE, Bergman T, Aase S Impact of azlo-cillin on the colon microflora. Scand J Infect Dis 1986,18 163-166. 

Silva M, Comick NA, Gorbach SL Suppression of colonic microflora by cefoperazone and evaluation of the drug as potential prophylaxis in bowel surgery. Antimicrob Agents Chemother 1989 33 835-848. 

Resistant starch will serve as primary source of substrate for colonic microflora and may have important physiological benefits. On this basis resistant starch can be classified as a dietary fibre. The Association of Official Agricultural Chemists (AOAC) method of determining dietary fibre will measure some resistant starch as dietary fibre. 

Lactobacillus preparation is intended to replace colonic microflora. This supposedly restores intestinal functions and suppresses the growth of pathogenic microorganisms. However, a dairy product diet containing 200 to 400 g of lactose or dextrin is equally effective in recolonization of normal flora. 

Mountzouris, K. C., Balaskas, C., Fava, F., Tuohy, K. M., Gibson, G. R., and Fegeros, K. (2006). Profiling of composition and metabolic activities of the colonic microflora of growing pigs fed diets supplemented with prebiotic oligosaccharides. Anaerobe 12,178-185. Mulvey, M. A. (2002). Adhesion and entry of uropathogenic Escherichia coli. Cell. Microbiol. 4, 257-271. 

Degradation of dosage form components by the enzymes of the colonic microflora... 

Deprez, S., Brezillon, C., Rabot, S., Philippe, C., Mila, I., Lapierre, C., and Scalbert, A., Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids, J. Nutr., 130, 2733, 2000. 

Polyphenols with attached glucose are potential substrates for endogenous human enzymes, while attached rhamnose is not a substrate for human (3-glucosidases and so is only cleaved by colon microflora a-rhamnosidases [63]. 

Evidence occurred that polymeric proanthocyanidins could be degraded by the colonic microflora into low-molecular-weight compounds, which would be subsequently absorbed. The group of Deprez... 

To date, the composition of the intestinal microflora still remains to be definitively described. However, it seems quite clear that it consists of a complex, symbiotic conglomerate of more than 500 different, predominantly anaerobic, strains. The enzymatic equipment of this symbiotically living colon microflora was adapted predominantly because of the changing types of food that were available during the course of evolution [36],... 

Figure 1 (A) Colon Microflora Test (CMT) device, an anaerobically working minifer-...

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