Annonaceous plants

The radiolabeling of potential precursor units would be the best way to study acetogenin biosynthesis however, the Annonaceous plants have proved very difficult to grow with any degree of speed in tissue culture. It seems that when the acetogenins are produced and... 

Nkunya, M.H.H. (1996). Unusual metabolites from Tanzanian Annonaceous plants The genus Uvaria. In Chemistry, Biological and Pharmacological properties of African medicinal plants. Hostettmann, K., Chinyangaynya, F., Maillard, M. and Wolfender, J.L. (Eds.), pp. 268-281. Proceedings of the first International IOCD symposium, Victoria Falls, Zimbabwe University of Zimbabwe. 

Examination of the stem-bark extract of Orophea enterocarpa led to the isolation of two new aristolactams, viz., enterocarpam-1 (17) and enterocarpam-II (19), accompanied by the known enterocarpam-I acetate (18) and enterocarpam-II acetate (20) [33]. Two new azafluorene alkaloids kinabaline (21) and oncodine (22) were obtained from the annonaceous plants Meiogyne virgala and Oncodostigma monosperma, respectively [34,35]. 

Table. 1. The Investigated Condition of Formosan Annonaceous Plants...

NITROGEN-CONTAINING CONSTITUENTS OF FORMOSAN ANNONACEOUS PLANTS... 

Six benzylisoquinolines were isolated from Formosan Annonaceous plants. Reticuline (A-l), the most frequently occurring... 

Tetrahydroprotoberberines (4H-protoberberin.es) There are four 4H-protoberberines described among Annonaceous plants in Taiwan Discretamine (A-15) was obtained from F. glauscense [21] Tetrahydropalmatine (A-16), from G. amuyon [A16], thaipetaline (A-17), from F. balance [22] and (-)-Kikenamine (A-18), from the stems of A. cherimola and F. balance [13,22]. Most of these 4H-protoberberines are 2,3,9,10-oxygenated derivatives and only A-17 was 2,3,4,9,10-oxygenated derivative. 

Antiplatelet Aggregation Activity. Alkaloids from Annonaceous plants were reported to inhibit platelet aggregation. According to our previous studies, more than twenty compounds were examined and most of the alkaloids were found inhibiting arachidonic acid (A.A) induced platelet aggregation [41]. Phenanthrene-alkaloids inhibited platelet aggregation initiated by four inducers (arachidonic acid, PAF, collagen, and thrombine)... 

Many Annonaceous plants are employed in folk medicine. Since Jolad et al. isolated the first Annonaceous acetogenins, uvaricin, which... 

Chemical studies—and to lesser extent pharmacological studies—on Annonaceous plants have been intensified in the last decade, though pioneering work started long ago. It is striking, however, as recently pointed... 

Briefly, Annonaceous plants are recognized, in tropical and subtropical regions, by the alternate, exstipulate leaves, mostly trimerous flowers, numerous and often truncate-free stamens, free carpels, and seeds with ruminate endosperm. ... 

Sixty-eight oxoaporphines were isolated from various Annonaceous plants, liriodenine (XI. 18) being ubiquitous. From the structural point of view, these oxoaporphines are rarely substituted at positions 4, 5, 8, and 11. 

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