Photodynamic antimicrobial

Tiwana, A. S. (2006). Antimicrobial photodynamic treatment for surface sanitation. (MSc thesis. University of Guelph, Canada). 

We have shown, in a series of reported experiments that cationic fullerenes fulfill many, but not all the aforementioned criteria. Our laboratory was the first to demonstrate that the soluble functionalized fullerenes described above, especially the cationic compounds BF4-BF6, were efficient antimicrobial PS and could mediate photodynamic inactivation (PDI) of various classes of microbial cells (Tegos et al., 2005). We used a broadband-pass filter giving an output of the entire visible spectrum (400-700 nm) to excite the fullerenes that maximized the absorption. 

Flamblin MR, Hasan T (2004) Photodynamic therapy a new antimicrobial approach to infectious disease 3 436—450. 

Hamblin, M. R. and Hasan, T. (2004). Photodynamic therapy A new antimicrobial approach to infectious disease. Photochem. Photobiol. Sci. 3, 436-450. 

Wainwright, M. (1998). Photodynamic antimicrobial chemotherapy (PACT). J. Antimicrob. Chemother. 42,13-28. 

New antimicrobial approaches that are effective, affordable, and widely applicable are urgently needed. The photodynamic method has been suggested as a possible new strategy for microorganism inactivation [1,2]. 

The work presented in the preceding pages described the antimicrobial, antioxidative, antiinflammatory, immunomodulatory, skin regenerating, photodynamic damage prevention and antiviral properties of Fraxinus ornus bark extract and its constituents. 

The total ethanolic extract of the stem bark and its main constituent esculin (1) were found practically non-toxic. They inhibited the classical pathway and alternative pathway of complement activation. The total extract and 1 displayed antiinflammatory activity in both zymosan- and carrageenan-induced paw edema in mice. The extract exhibited a pronounced antioxidative activity and caused intense wound epithelization. The antimicrobial and photodynamic damage prevention properties of the extract and its fractions were dependable on their... 

Like the examples cited above, there are several current hot topics of research in photosensitization, including the use of photodynamic therapy for malignancies, the use of photosensitizers as model systems for studying physiological and pathological processes involving reactive oxygen species, the development of model systems to produce cerebral ischemia, the use as antimicrobials and to treat blood and blood products, and photosensitization in the cardiovascular system, the main topic area of this review. 

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