Antihypoxic activity

Much more exciting biologic properties have been revealed for the equally 1,6-disubstituted phenazoviridin (56) isolated from Streptomyces sp. HR04. The new free radical scavenger showed strong in vitro inhibitory activity against lipid peroxidation and displayed in vivo antihypoxic activity in mice [57]. 

Monosilamorpholinones Antihypoxic Activity against Chlorphos-poisoning... 

Dimethylamino)phenylgermatrane, belonging to the series of nitrogen-containing phenylgermatranes, shows reliable antihypoxic activity, prolonging the life by 55.4%. 

Adamantylgermatrane has been studied more thoroughly during its administration to the stomach in doses from 5 to 250 mg kg-1. Administer p.o., it also reveals pronounced antihypoxic activity which increases with dose. 1 -Adamantylgermatrane in doses of 50-250 mg kg-1 reveals antihypoxic potency also at haemic hypoxia10. 

Zablotskaya A et al. [72] prepared trimethylsilyl ethers of different hydroxyl group bearing thiazole compounds. All the compounds examined possess antihypoxic properties and extend the life of mice under conditions of hypoxia by 20-78%. The silylated and unsilylated derivatives in the preponderance of circumstances show antihypoxic activity. 

Following the action of extraordinary stimulants (hypoxic hypoxia, hypoxia + hyperoxia, hypodynamia + hyperthermia), animals demonstrate an accumulation of malonic dialdehyde with a simultaneous fall of antiradical activity of the liver tissue. A preliminary introduction to rats of acetylene amine 3,4,5-tris(morpho-linopropynyl)-l-methylpyrazole 103 and also of tocopherol antioxidant and gutumine antihypoxant averts activation of the lipid peroxidation processes. The inhibition of peroxidation with this agent is mediated by stabilization of ly-zosomal and mitochondrial membranes. Unsaturated amines prevent destruction of the organelle membranes provoked by UV irradiation and incubation at 37°C (pH4.7)(78MIl). 

A series of 2-siIa-5-morpholinones have been prepared and their biological activity evaluated. They are found to exhibit certain antihypoxic property in animals tested against chlorphos-poisoning.504,505 2,2,4-Trimethyl-6-phenyl-2-sila-5-morpholinone (A R = Ph) displays a cold-resistant activity.504... 

Proanthocyanidins - These are polyphenol compounds, which possess pronounced antihypoxic, antioxidant and antiinflammatory actions. They have vitamin-P activity. 

Documented effects A dry extract from the aboveground parts, as well as the total proanthocyanidins have antihypoxic, antioxidant, angioprotective, and hypocholesterimic abilities (Aizikov et al. 1986). An ethanolic extract of the aboveground plant parts had antiulcerogenic activity in rats (Amani et al. 2006), and a methanolic extract exhibited an antidiarrheal effect (Atta and Mouneir 2004). 

Ginkgo leaf extract has vascular tone-regulating properties, an antihypoxic effect, experimental inhibitory activity in cerebral edema, and neurotoxicity modulates cerebral energy metabolism free radical scavenging properties inhibits lipid peroxidation of membranes, helping to maintain integrity and permeability of cell walls antiasthmatic, bronchodilator, and so on. (wren). 

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