Antihaemophilic factor

VIII Antihaemophilic factor Intrinsic Accessory protein, enhances activation of X (intrinsic system)... 

Legaz, M.E., Schmer, G., Counts, R.B., and Davie, E.W. 1973. Isolation and characterization of human factor VIII (antihaemophilic factor). Journal of Biological Chemistry 248, 3946-3955. 

A new initiative is a prostaglandin analogue latanoprost, a synthetic derivative of PGFja, used topically in open-angle glaucoma and ocular hypertension in patients unresponsive to other drugs (see prostanoid receptor AGONIST), antihaemophilic factor factor VIII. 

Mia. McLester, W. D., and Graham, J. B., Gene expression in heterozygotes and synthesis of plasma antihaemophilic factor. Nature 201, 1040-1042 (1964). 

P6. Propp, 8., and Dylong, V. M., High antihaemophilic factor in multiple myeloma. Nature 207, 206 (1965). 

Kl. Kekwick, R. A., and Walton, P. L., An assay for antihaemophilic factor (factor VIII) with some considerations affecting the establishment of a standard reference preparation. Brii. J. Haematol. 10, 299-313 (1964). 

VIII Antihaemophilic Factor Protein cofactor for Factor IX, Classic haemophilia Haemophilia A... 

Factor IXg is responsible for activating Factor X in a reaction that is enhanced some 10 -10 times by the presence of three accessory factors. These are a charged phospholipid surface, e.g. everted platelet membrane, Ca " " ions and a very large auxiliary protein. Factor Villa antihaemophilic factor) which circulates in the blood in an inactive form. This complex of proteins, Ca " " and phospholipids is sometimes referred to as tenase since it converts Factor X into its active form (Factor X ). 

In haemophilia A antihaemophilic globulin (factor VIII) concentrate (t) 8-12 h) should be used for bleeding that is more than minor. Administration of each unit of factor VIII per kg body weight raises the plasma level by 2%. Repeat dosing 2-3 times daily is necessary to maintain levels. 

HI. Hardisty, R. M., and Macpherson, J. C., A one-stage factor VIII (antihaemophilic globulin) assay and its use on venous and capillary plasma. Thromb. Diath. Haemorrhag. 7, 215-229 (1962). 

Treatment of both conditions is by replacement of the missing factor. Antihaemophilic globulin and Christmas factor complex are prepared from fresh normal plasma. Replacement therapy is used to treat haemorrhage and prophylactically before surgery or dental treatment. 

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