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Antigens signal transduction

Geng, Y. et al., Effects of nicotine on the immune response. I. Chronic exposure to nicotine impairs antigen receptor-mediated signal transduction in lymphocytes, Toxicol. Appl. Pharmacol., 135, 268-287, 1995. [Pg.539]

Sugawara H, Kurosaki M, Takata M, Kurosaki T 1997 Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J 16 3078-3088... [Pg.146]

Thus, the KOB cells have been demonstrated ex vivo to prevent apoptosis by expression on their surfaces of function-ablating Fas antigen, which lacks the entire death domain. These aberrant Fas molecules probably behave as decoy receptors and interfere with the trimerization of normal Fas in a dominant negative manner, resulting in the impairment of signal transduction. [Pg.131]

Qian, D. and Weiss, A. T cell antigen receptor signal transduction (1997) Curr. Op. Cell Biol. 9, 205- 212... [Pg.376]

Weiss, A. and littman, D.R. Signal transduction by lymphocyte antigen receptors (1994) Cell 76, 263-274... [Pg.376]

Blocks the function of CDS molecule in the membrane of human T cells, which has been associated in vitro with the antigen recognition structure of human T cells that is essential for signal transduction... [Pg.15]

CD21 130 (soluble), 145 (membrane-bound) B cells, follicular dendritic cells Receptors for various antigens. Involved in signal transduction... [Pg.10]

The TCR is composed of integral membrane protein that recognizes the antigen and as a consequence its activation produces an immune response to eliminate the antigen. This process results in the development of CD4+ or CD8+ cells from the precursor T cells. It involves other cell surface receptors and downstream signal transduction mechanisms. [Pg.21]

The monoclonal antibodies used as immunosuppressive agents in tissue transplantation include muromonoab-CD3, daclizumab and basiliximab. Muromonoab-CD3 binds to a specific site on CD3 receptors and interferes with the ability of the TCR to bind the antigen and also inhibits CD3 receptor-dependent signal transduction mechanisms, all of which result in immune suppression. Both daclizumab and basiliximab are monoclonal antibodies directed against IL-2 receptors and consequently inhibit IL-2-dependent responses after tissue transplantation, resulting in immune suppression. The monoclonal antibodies used as immunosuppressive agents are described in detail in Chapter 5. [Pg.102]

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See also in sourсe #XX -- [ Pg.23 , Pg.24 , Pg.25 ]



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