Antigen-specific T cell activation

Quintana FJ, Gerber D, Kent SC, Cohen IR, Shai Y (2005) HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Chn Invest 115 2149-2158 Reeves JD, Gallo SA, Ahmad N, Miamidian JL, Harvey PE, Sharron M, Pohlmann S, Sfakianos JN, Derdeyn CA, Blumenthal R, Hunter E, Dorns RW (2002) Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc Natl Acad Sci USA 99 16249-16254... 

Funatake, C.J. et al., 2004. Early consequences of 2,3,7,8-trtrachlorodibenzo-p-dioxin exposure on the activation and survival of antigen-specific T cells. 

Antigen presentation is essential for the maintenance of antigen-specific T cell responses in the nervous system (Groux etal., 2004 Karman etal., 2004). How this occurs remains incompletely defined. Although it is now well accepted that DC are the most potent APC type responsible for any primary immune response and occur through a strong and sustained ability to activate naive T cells the role of these cells in CNS immunity is hotly contested. The reasons are numerous. First, the differential phenotypes of DCs make their functional characterization in the nervous system difficult. Second, DCs are... 

A schematic view on the main processes that lead to autoimmune central demyelination is presented in Figures 18.2 and 18.3. Autoreactive, myelin antigen-specific T cells are part of the normal T-ceU repertoire, although at low frequency. These cells are thought to be activated in the peripheral immune system... 

Greten TF, Slansky JE, Kubota R, Soldan SS, Jaffee EM, Leist TP, Pardoll DM, Jacobson S, Schneck JP (1998) Direct visualization of antigen-specific T cells HTLV-1 Tax 11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients. Proc Natl Acad Sci USA 95 7568-7573. 

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