Antigen activation

CLL is characterized by small, relatively incompetent B lymphocytes that accumulate in the blood and bone marrow over time. The exact cell of origin is controversial but has been described as an antigen-activated B lymphocyte.3... 

Human cytomegalovirus glycoprotein B Tobacco seed gB-specific antigenic activity. - 42, 96... 

Figure 9.3 Activation of T-cells by interaction with macrophage-displayed antigen. Activation results in IL-2 production, which acts in an autocrine manner to stimulate further T-cell growth and division. IL-2 thus represents the major regulatory molecule responsible for stimulation of cell-mediated immunity. Note that it was initially believed that binding of presented antigen alone was insufficient to trigger T-cell activation. It was thought that co-stimulation with IL-1 was reguired. However, the assay used to detect the co-stimulation was found not to be specific for IL-1 alone. The role of IL-1 as a co-stimulator of T-cell activation is now believed to be minimal at most...

Figure 8. Antigenic sites in the fusion region of influenza virus hemagglutinin of strains A and B. The sites have been localized and their antigenic activity confirmed by synthesis and reactivity with rabbit, goat, and mouse antivirus and antihemagglutinin antibodies. Also, each of the peptides bound considerable amounts of anti-influenza antibodies from sera of human individuals after influenza attack. Reproduced with permission from Ref. 29.

First, oligosaccharide 1 (see Table X) represents that structure shown by serological tests285 to be largely responsible for Le antigenic activity. Both this structure and the disaccharide N-acetyl-... 

The antigenic activity of the keratan sulfate-like, protein complex from chick allantoic fluid results mainly from the presence of relatively large proportions of prosthetic groups (hexasaccharides) that differ greatly from that usually described as keratan sulfate.293 This complex is immunologically identical with a component of influenza-virus envelope.294... 

Extensive purification of the glycosphingolipids present in the neutral fraction resulted in the isolation of three distinct glycolipids exhibiting Forssman antigenic activity (Table I, compounds 9,10,11). Thin-layer chromatographs of these glycolipids is illustrated in Fig. 1. Chemical analyses of the purified... 

Denmeade, S. R., Jakobsen, C. M., Janssen, S., Khan, S. R., Garrett, E. S., Lilja, H., Christensen, S. B. and Isaacs, J. T., 2003, Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J Natl Cancer Inst 95, 990-1000. 

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