Antifungal activity/agents

S., Artico, M., Costi, R., Di Santo, R., Ragno, R. Molecular modeling of azole antifungal agents active against Candida albicans. 1. A comparative molecular field analysis study. J. Med. Chem. 1996, 39, 1227-1235. 

Fig.4a-h. Topical antifungal agents active moieties, a tolnaftate b haloprogin c chlordan-toin d mesulphen e dibenzthione f fluonilid g pecilocin h mycanodin... 

For example, Ghorab and coworkers exploited the classical Biginelli reaction to synthesize a variety of potentially active antifungal agents such as 56 from DHPM 55. ... 

Nafimidone (93), an anticonvulsant compound, also contains an imidazole moiety It seems to have been discovered by accident during a search for antifungal agents Its synthesis is straightforward involving displacement with imidazole of the activated chlorine atom of chloro-methyl-p-naphthylketone (92) [32]... 

The sensitivity of barley to the toxin increases as the stage of germination advances. This may be partially explained by the presence of antifungal agents in the young plant whose activity is reduced with age (8,12). Further progress on the chemistry of this material is reported by Stoessl (14). 

Several coumarin derivatives have revealed pronounced medicinal value as antibacterial and antifungal agents [57,58]. Others have displayed antituber-cular activity [59] and some have insecticidal properties [60]. This prompted us to investigate the preparation of a new series of compounds containing coumarin moieties with different side chains or fused rings. 

Silver and its compounds have long been used as antimicrobial agents in medicine. The mechanisms of silver toxicity as they relate to human exposure to pharmaceuticals have been reviewed (328). Silver is active at low concentrations and has a low toxicity. The practice of instilling the eyes of infants with 1% of AgN03 solution immediately after birth is still common in some countries, for prevention of opthalmia neonatorum (329). Silver sulfadiazine 77 is clinically used as a topical antimicrobial and antifungal agent and applied as a cream to prevent bacterial infections in cases of severe burns. It is an insoluble polymeric compound and releases Ag(I) ions slowly. 

Morgan, B., Dodds, D.R., Zaks, A., Andrews, D.R. and Klesse, R., Enzymatic desymmetrisa-tion of prochiral 2-substituted-l,3-propanediols apracticalchemoenzymatic s3mthesis of akey precursor of SCH51048, a broad-spectrum orally active antifungal agent. J. Org. Chem., 1997, 62, 7736-7743. 

In the case of the prescription relating to Daktacort (Q91-94), for candidates not familiar with its use, it is important to identify the active ingredients. Daktacort is listed in the BNF under hydrocortisone but its main use is as an antifungal agent. 

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