Antidotes tabun

Nerve Agent Antidote Kit (NAAK or MARK I) consists of an atropine auto-injector (2 mg), a pralidoxime chloride auto-injector (2-Pam-Cl, 600 mg), the plastic clip joining the two injectors, and a foam case. The kit serve as a countermeasure to nerve agents, including tabun (GA), sarin (GB), soman (GD), GF, and VX. Military personnel can receive three MARK I for self/buddy aid. Possible side effects of atropine and/or 2-PAM-C1 are deemed insignificant in a nerve agent casualty. Intravenous atropine and 2-PAM-C1 can also be made available. The MARK I kit is manufactured by Survival Technology, Inc., Rockville, Maryland. 

All the synthesized compounds were tested both in vivo on mice intoxieated by soman or tabun and in vitro on human erythrocyte AChE. In conclusion, nitro, sulfone, amino, and aminosulfonyl side-chain substituents caused high antidotal activity, where the optimum length of side-... 

Kuca, K., Jun, D., Kim, T.H., Cabal, J., Jung, Y.S. (2006). In vitro evaluation of new acetylcholinesterase reactivators as causal antidotes against tabun and cyclosarin. Bull. Korean Chem. Soc. 27 395-8. 

Gender differences are observed in the antidotic-and-therapeutic action of oximes. The single administration of an oxime concurrently with atropine protects males from 4.2 DL50 of soman and 2.5 DL50 of tabun, with respective values for females being 10.5 and 4.3 DL50 [79],... 

Efficacy of the anticonvulsant usage in antidotic formulas depends considerably on OPC type. Thus, index of protection (IP) for the composition of ChR (HI-6 inclusive), cholinolytics and diazepam is much higher for the treatment of intoxication with soman and tabun, than in poisonings with sarin and VX [93],... 

Hildebrandt, H. J., Combined antidote therapy in animals poisoned with tabun, sarin and soman. Naunym-SchmiedebergsArch. Pharmacol. Exp. Pathol., 263,222-223,1969. 

Soman at doses of 1.0 and 1.2 mg/kg inhibited spinal cord NTE (67 and 37% of control, respectively) in hens protected with the antidote, atropine. Tabun at a dose of 12 mg/kg decreased NTE activity (67% of control) in the spinal cord of protected hens. The inhibition of NTE activity in these studies were below threshold levels and suggested the inability of soman and tabun to cause OPIDN. Rats exposed to low-dose sarin (300 p,g/kg, p.o.) for 90 days significantly inhibited brain NTE activity (85% of control). " Crowell et al."° studied the effects of oral graded... 

Antidotes for tabun are same as those for other nerve agents (see Section 39.3). Kassa... 

K39. Krejcova, G., and Kassa, J., Neuroprotective efficacy of pharmacological pretreatment and antidotal treatment in tabun-poisoned rats. Toxicology 185, 129-139 (2003). 

Recovery from tabun exposure is possible w ith treatment, but the antidotes available must be used quickly to be effective. Therefore, the best thing to do is avoid exposure ... 

Treatment consists of removing tabun from the body as soon as possible and providing supportive medical care in a hospital setting. Antidotes are available for tabun. They are most useful if given as soon as possible after exposure. 

Kassa, J., Karasova, J.Z., Pavlikova, R., et al., 2010. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice. J. Appl. Toxicol. 30,120-124. 

Kassa, ]., 2006. Therapeutic and neuroprotective efficacy of pharmacological pretreatment and antidotal treatment of acute tabun or soman poisoning with the emphasis on pretreatment drug PANPAL. Arh. Hig. Rada Toksikol. 57, 427-434. 

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