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Antidiarrhoeal drugs

Antidiarrhoeal drugs are used for the symptomatic treatment of diarrhoea (the frequent passage of liquid... [Pg.125]

Loperamide is an antidiarrhoeal drug indicated for use in adults and children over 12 years. Loperamide should not be administered in children under 4 years v/ho have diarrhoea. Children are more sensitive to the occurrence of the side-effect of respiratory depression. Fluid and electrolyte replacement are first-line treatments in diarrhoea. [Pg.301]

Antidiarrhoeals are given for symptomatic relief of diarrhoea. The first step in treatment of acute diarrhoea is replacement of fluid and electrolytes. If due to diarrhoea there is severe dehydration, it requires immediate hospitalization for IV fluid and electrolyte replacement. Antidiarrhoeal drugs are administered for obtaining symptomatic relief in acute diarrhoea but have untoward effects. Alongwith antidiarrhoeal drugs, antispasmodics are administered in those patients who have diarrhoea with abdominal pain. [Pg.255]

The antidiarrhoeal drug ipecac, which was introduced into Europe from Brazil in 1658, contains the amoebicidal alkaloids emetine (12) and cephaeline. Emetine remained the major remedy for amoebic dysentery and amoebic hepatitis for many years. Cephaeline is less active and more toxic. ( j-2-Dehydroemetine, which is made by synthesis, is equiactive with (—)-emetine and less toxic, but other chemical modification has not yielded better amoebicides. From investigations of synthetic routes to the benzoquinolizine moiety the tranquilizer tetrabenazine (13a) was discovered. The very similar compound benzquinamide (13b) is also a tranquilizer and antiemetic. [Pg.147]

Haskins, N. J., Ford, G. C., Grigson, S, J., and Waddell, K. A. (1978). A carrier effect observed in assays for antidiarrhoeal drug compounds. Biomed. Mass Spectrom. 5, 423-424. [Pg.156]

Beubler and Badhri (1990) used the PGE2-induced net fluid secretion in the jejunum and colon in the rat to evaluate the antisecretory effects of antidiarrhoeal drugs. Polyethylene catheters were placed into the jejunum and colon and Tyrode solution was instilled into the loops. Net fluid transfer rates were determined gravimetrically 30 min after instillation of Tyrode solution. [Pg.177]

Many centres co-prescribe an antidiarrhoeal drug such as loparmide to use in case of diarrhoea. Mrs RP should be counselled to use this to treat diarrhoea should it occur again. [Pg.217]

CHLOROQUINE ANTIDIARRHOEAL DRUGS-KAOLIN i chloroquine levels 1 absorption Separate doses by at least 4 hours... [Pg.584]

PROTEASE INHIBITORS ANTIDIARRHOEAL DRUGS-LOPERAMIDE t risk of adverse effects when loperamide is co-ingested with ritonavir Ritonavir inhibits P-gp and CYP3A4 Monitor for clinical effect, and consider 1 dose if necessaiy. Stop if there are signs of abdominal distension in HIV patients as toxic megacolon has been reported... [Pg.617]

Ruppin H 1987 Loperamide a potent antidiarrhoeal drug with actions along the alimentary tract. Alimentary Pharmacology and Therapeutics 1 179-190 Rutkowski J A, Eades S C, Moore J N 1991 Effects of xylazine butorphanol on cecal arterial blood flow, cecal mechanical activity and systemic hemodynamics in horses. American Journal of Veterinary Research 52 1153-1158... [Pg.119]

Tariq Babhair SA. Effect of antacid and antidiarrhoeal drugs on the bioavailability of indenolol. (1984) 12, 87-8. [Pg.834]

Mazzitelli M, Brega G, Dirani D, Andalo A Antidiarrhoeal effectiveness and tolerance in man of a local antibiotic Rifaximin. Comparative assessment using a control drug. Eur Rev Med Pharmacol Sci 1984 6 301-306. [Pg.80]

Despite the lack of studies correlating the antidiarrheic activity of crude drugs with the presence of flavonoids, these have been also studied as pure compounds in this regard. The most used assay of antidiarrhoeic activity is the castor oil test, in which diarrhea is induced by the oral administration of castor oil to mice. Different flavonoids have been shown to possess antidiarrheal activity in this test quercetin, kaempferol, morin, myricetin, rutin (i.p.) [117,118], quercitrin (p.o.) [114,119], and tematin (i.p.) [44], all showing a dose-dependent activity in the range between 25 and 100 mg/kg. However, flavonoids are not only able to exert a preventive antidiarrheal effect in this acute model of experimentally-induced diarrhea, but also in chronic models. Thus quercitrin showed beneficial effects in a model of lactose-induced chronic diarrhea in rats, since it reduced the diarrheal output and facilitated colonic mucosal repair in lactose fed [120]. [Pg.620]

DRUGS ACTING ON THE GASTROINTESTINAL TRACT ANTIDIARRHOEALS Kaolin... [Pg.636]

For full details of potential interactions, see Drugs Acting on the Gastrointestinal Tract, Antidiarrhoeals... [Pg.767]

Adsorption is a non-specific process and, as well as adsorbing toxins, bacteria and water, the drugs may interfere with the absorption of other drugs from the intestine. This should be borne in mind if recommending adsorbent antidiarrhoeals to patients taking other medicines. [Pg.79]

Peripheral opiate receptors have be n identified in the ileum and are responsible for the antidiarrhoeal activity of opiates. If peripheral sensory nerves also possess opiate receptors, drugs might be designed versus these sites and as a result would not need to cross the blood-brain barrier. [Pg.280]

Yegnanarayan R, Shrotri DS 1982 Comparison of antidiarrhoeal activity of some drugs in experimental diarrhoea. Indian J Pharmacol 14 293-299... [Pg.1163]


See other pages where Antidiarrhoeal drugs is mentioned: [Pg.125]    [Pg.125]    [Pg.643]    [Pg.33]    [Pg.271]    [Pg.125]    [Pg.125]    [Pg.643]    [Pg.33]    [Pg.271]    [Pg.72]    [Pg.72]    [Pg.619]    [Pg.397]    [Pg.636]    [Pg.828]    [Pg.830]    [Pg.31]    [Pg.28]    [Pg.101]    [Pg.186]    [Pg.208]    [Pg.14]    [Pg.448]    [Pg.36]    [Pg.38]    [Pg.65]   


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Antidiarrhoeal

Antidiarrhoeals

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