Anticoagulants formulas

Therapeutic Function Anticoagulant, Vitamin K antagonist Chemical Name 3-(Q -acetonyl-p-nitrobenzyl)-4-hydroxycoumarin Common Name Nicoumalone Structural Formula ... 

Therapeutic Function Anticoagulant Chemical Name See structural formula Common Name —... 

Structural formulas of several oral anticoagulant drugs and of vitamin K. The carbon atom of warfarin shown at the asterisk is an asymmetric center. 

If patients are on anticoagulants, herbal formulas that promote blood circulation and break up congealed blood should be used with caution. 

Formula A Anticoagulant citrate dextrose solution (ACD) Apheresis devices Braintree, MA 02184 ... 

AS3 nutricel additive system additive solution formula 3 Anticoagulant citrate phosphate 2X dextrose solution To provide the CP2D during collection and add AS3 to the separated red blood cells in order to extend the length of time they can be stored 001214 Gambro BCT, Inc. 10811 W. Collins Ave. Lakewood, CO 80215 May 29, 2002... 

Therapeutic Function Anticoagulant, Antithrombotic Chemical Name Heparin, compounds, sodium salt Common Name Dalteparin sodium Tedelparin 4-6 Structural Formula Heparin, compounds, sodium salt... 

The cone-and-plate viscometer is an in vitro flow model used to investigate the effects of bulk fluid shear stress on suspended cells. Anticoagulated whole blood specimens (or isolated cell suspensions) are placed between the two platens (both of stainless steel) of the viscometer. Rotation of the upper conical platen causes a well-defined and uniform shearing stress to be applied to the entire fluid medium as described by Konstantopolous et al. (1998). The shear rate (y) in this system can be readily calculated from the cone angle and the speed of the cone using the formula i/ = where y is the shear rate in sec-1, mis the... 

Source Ruta graveolans. Molecular formula C27 H30 O le. Molecular weight 610.57. Biological activity Anticoagulant. 

Anticoagulant activity in vitro calculated from the number of micrograms of dextran sulphate and heparin required to give 50 per cent inhibition of coagulation of 1 ml. dog plasma. Anticoagulant activity in vivo calculated from Lee and White clotting times at 0, 1, 2, 3 hours after intravenous injection in rabbits of 3 mg/kg. Peak = peak clotting times. Area = area under the curve with formula of Millar, Jaques and Henriet suitably modified. Values for heparin were activity in vitro, 3-5 g in vivo, peak = 100 (92-108) minutes area = 0-20 LDg = 220 42 mg/kg. 

FIGURE 54-5 Structural formulas of the oral anticoagulants. 4-Hydroxycoumarin and indan-l,3-dione are the parent molecules from which the oral anticoagulants are derived. The asymmetrical carbon atoms in the coumarins are shown in hlue. 

International normalised ratio (INR). The DSTR was adopted by the WHO in 1982 to standardise (using the International Sensitivity Index) oral anticoagulant therapy to take into account the sensitivities of the different thromboplastins used in laboratories across the world. The formula for calculating the INR is as follows ... 

Some furanophenathrenequinones are exemplified in formulae 10-187 to 10-189. In addition to these compounds, another group of quinones includes their isopropyl derivatives, such as ros-mariquinone (10-185), which is also found in rosemary, miltirone (10-190), dehydrorosmariquinone (10-191), danshenxinkuns A (10-190), B and C (10-192). In addition to antioxidant activity, these substances also have sedative, antimicrobial, anticoagulant, anti-inflammatory and other effects. In addition to these compounds, other components include rosmarinic acid (8-83) and a number of its derivatives. 

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