Anticholinergic effect viloxazine

Viloxazine Bicyclic Fewer anticholinergic or sedative effects and weight gain Causes nausea, vomiting, and weight loss Can precipitate migraine... 

Viloxazine, a bicyclic compound, is related structurally (but not pharmacologically) to the beta-adrenoceptor antagonists. In animal tests, its profile shows properties of both the imipramine-like compounds (reversal of reser-pine-induced hypothermia) and amphetamine (stimulation of the electroencephalogram). A review of animal and clinical data confirmed the impression that viloxazine has efficacy comparable to that of imipramine but with a different adverse effects profile (1). There is a reduced frequency of anticholinergic and sedative effects and a tendency to lose rather than to gain weight. However,... 

The selective inhibition of NA uptake by viloxazine, in the absence of effects on DA or 5-HT uptake, resided in the trans-S-isomer, paralleling the reserpine reversal effects.81 The anorectic drug mazindol was also a potent inhibitor of NA uptake,82 like its structural relative ciclazindol (22).83 In a double-blind trial, 2 was as effective as amitriptyline in ameliorating endogenous depression. Ciclazindol, which lacked significant anticholinergic or cardiotoxic effects, produced fewer side-effects than amitriptyline. Diverse structures included befuraline (DIV 154, 23) an... 

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