Antibacterial polyurethanes

Advances in Polyurethane Biomaterials. http //dx.dol.Org/10.1016/B978-0-08-100614-6.00009-3 Copyright 2016 Elsevier Lid. All rights reserved. 

Bacterial adhesion is the altical step in the pathogenesis of biomaterial-associated infection and is critically inflnenced by numerous variables including surface properties of biomaterials, the nature of the environment, and the bacterial cell surface. In addition, adsorbed proteins play an important role in bacteria-surface interactions. One strategy for the development of antibacterial polyurethanes has focused on 

Cast PDMS on PDMS negative Cast PU on PU positive 

The fractions of total top surface area of pillars are 25.2% of the nominal surface area for 500/500nm pattern and 51.6% for 4.0/1.5 pm pattern. Since the submicrometer patterned surface has low accessible surface contact area and is less energetically favorable for bacterial interactions, bacterial adhesion is inhibited however, the bacterial adhesion on a micropattemed surface (e.g., 4.0/1.5 pm) is more dependent on surface wettability (see below). 

3 Synergetic antibiofouling by combination of chemicai and physical treatments 

---

Fong N, Simmons A, Poole-Warren LA. Antibacterial polyurethane nanocomposites using chlorhexidine diacetate as an organic modifier. Acta Biomater 2010 6 2554-61. 

Other strategies of antibacterial polyurethanes and future perspectives... 

Park D, Larson A, Klibanov A, Wang Y. Antiviral and antibacterial polyurethanes of various modalities. Appl Biochem Biotechnol 2013 169 1134-46. http //dx.doi.org/ 10.1007/S12010-012-9999-7. 

Bakhshi H, Yeganeh H, Mehdipour-Ataei S. Synthesis and evaluation of antibacterial polyurethane coatings made from soybean oil functionalized with dimethylphenylam-monium iodide and hydroxyl groups. J Biotned Mater Res A 2013 101A 1599-611. http //dx.doi.org/ 0.1002/jbm.a. 34461. 

Unnithan, A.R., Gnanasekaran, G., Sathishkumar, Y., Lee, Y.S., Kim, C.S., 2014. Electro-spun antibacterial polyurethane-ceUulose acetate-zein composite mats for wound dressing. Carbohydrate Polymers 102, 884-892. http //dx.doi.Org/10.1016/j.carbpol.2013. 10.070. 

---