Anti-inflammatory activities cytotoxic activity

Boonphong S, Puangsombat P, Baramee A, Machidol C, Ruchirawat S, Kittakoop P. (2007) Bioactive compounds from Bauhinia purpurea possessing antimalarial, antimycobacterial, antifungal, anti-inflammatory and cytotoxic activities. J Nat Prod 70 795-801. 

A number of dimeric carbazole alkaloids have been isolated from various natural sources in recent years, which have been found to exhibit various biological activities including antitumor, anti-inflammatory, and cytotoxic activities. In 1996, clausenamine A was isolated from the stem and root bark of Clausena excavata, which is used in Chinese herbal medicine for detoxification treatment following poisonous snakebites. The first total synthesis of clau-... 

BCaUeh, M., W.V. Berghe, E. Boone, T. Essawi, and G. Haegeman. 2007. Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. /. Ethnopharmacol. 113(3) 510-516. 

Phrutivorapongkul, A. et al.. Studies on the chemical constituents of stem bark of Millettia leucantha isolation of new chalcones with cytotoxic, antiherpes simplex virus and anti-inflammatory activities, Chem. Pharm. Bull, 51, 187, 2003. 

States, Canada, and Europe. The Food and Drug Administration has also approved Novantrone, a cytotoxic agent with associated anti-inflammatory activities, for the treatment of patients with secondary progressive multiple sclerosis based on a phase III trial that provided clinical and MRI evidence of reduced disease activity. 

Iwli et al [97] have reports based on the evaluation of plant-extract of D. multiradiata for antileishmanial activity using a mechanism-based radiorespirometric micro-technique. Extracts were found to be active at concentrations of 50 pg/ml or less against a visceral leishmania isolate. A number of Dorstenia species used traditionally as anti-snake venom were subjected to a pharmacological screening process and were found to possess analgesic and anti-inflammatory activities [98]. Many of the flavonoids isolated from African Dorstenia show moderate to good antioxidant activities [Croft, unpublished results]. The cytotoxic properties of... 

Clofazimine [kloe FA zi meen] is a phenazine dye that binds to DNA and inhibits template function. Its redox properties may lead to the generation of cytotoxic oxygen radicals that are also toxic to the bacteria. Clofazimine is bactericidal to M- leprae and has some activity against M- avium intracellulare complex. On oral absorption, it accumulates in tissues, allowing for intermittent therapy, but it does not enter the CNS. Patients may develop a red-brown discoloration of the skin. Eosinophilic enteritis has been reported as an untoward effect. The drug also has some anti-inflammatory activity, thus erythema nodosum leprosum does not develop. 

DEMETZOS, C., DIMAS, K., HATZIANTONIOU, S., ANASTASAKI, T., ANGELOPOULOU, D., Cytotoxic and anti-inflammatory activity of labdane and cis-clerodane type diterpenes., Planta Med., 2001,67,614-618. 

Pseudopterosin A (129), which is a diterpene glycoside isolated from the sea whip Pseudopterogorgia elisabethae, shows anti-inflammatory activity by inhibiting release of leukotriene B2 from leukocytes (2, 35). A more interesting class of diter-penes includes sarcodictyn A (130) and elentherobin (131), which were isolated from the soft corals Sarcodictyon roseum and Eleutherobia sp., respectively. These diterpenoids show potent cytotoxicity by stabilizing microtnbnles (2, 35). 

Later was reported that variabilin (7a) is a good inhibitor of human secretory and cytosolic PLA2 with anti-inflammatory activity [32] and shows in vitro antiviral activity against Herpes simplex (HSV) and Polio vaccine (PV1) viruses [33]. The high cytotoxicity against the BSC cell line exhibited by variabilin severely limits its potential usefulness as antiviral agent [33]. 

Abstract In the current presentation, our latest results performed on Lycopodium clavatum L. the most common species in Turkey, are given in terms of biological activity, which include antibacterial, antifungal, antiviral, cytotoxic, antioxidant, anti-inflammatory and immunomodulatory activities of this fern. Antioxidant activity of the plant was assessed on the basis of the radical scavenging effect of the stable... 

Cytotoxic T Anti-Inflammatory Activation of B cells to make antibodies Produces IL-4, IL-5, IL-6, IL-10, IL-3, GM-CSF, and IL-13 Induce IgGI CD8+... 

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