Anti-infective agent antibacterial

Stockley IH. Antibacterial and anti-infective agent drug interactions. In Stockley IH, ed. Stockley s drug interactions. 6th ed. London Pharmaceutical Press 2002. p. 128-232. 

Charifson, P.S., Grossman, T.H., Mueller, P. The use of structure-guided design to discover new anti-microbial agents Focus on antibacterial resistance. Anti-Infective Agents Med. Chem. 2009, 8, 73. 

Uses This compound is used as an anti-infective agent antiamoebic agent intravaginal trichomonacide used to impregnate cotton bandages for antibacterial purposes in animals as an intestinal anti-infective agent. UCU A... 

Recent synthesis of marine natural products with antibacterial activities. Mancini, I., Defant, A., GueUa, G. (2007), Anti-Infective Agents in Medicinal Chemistry (formerly Cun. Med. Chem.-Anti-Infective Agents), 6,17-48. 

Sulfonamides are antibacterial agents, meaning they are active against bacteria Another term that may be used to describe the general action of these drugs is anti-infective because they are used to treat infections caused by certain bacteria Sulfadiazine, sulfisoxazole, and sulfamethizole are examples of sulfonamide preparations. 

Fnlco P, Wenzel RP. (2006) Ramoplanin a topical lipoglycodepsipeptide antibacterial agent. Expert Rev Anti-Infect Ther 4 939-945. 

Viruses are obligate intracellular organisms as their replication is based on DNA and RNA dependent processes and protein synthesis of the host. Antiviral therapy can therefore not be as selective as antibacterial treatments and anti-viral agents tend to inhibit host cell function and can cause major toxicity. An other problem with antiviral therapy is the fact that active viral replication mostly takes place before symptoms become manifest. Our armamentarium against most viral infections is limited. 

Bacterial membranes have a much more complex construction than mammalian membranes. This enables bacteria to survive in the various environments of host organisms. Knowledge of the composition and functioning of bacterial membranes is therefore essential to the development of anti-infective drugs. In order to be effective, antibacterial agents not only have to have optimal pharmacokinetic properties such as uptake and distribution in the patient, but they must also be able to cross an additional barrier, the cell wall of the bacteria, so that they can reach the target site. This additional barrier is remarkable on account of its rigidity and permeability. The construction and structural uniqueness of this barrier is briefly described below. 

Modern anti-infective chemotherapy is founded on the deployment of an arsenal of potent and safe small-molecule inhihitors of microbial growth. As a result, it is not an understatement to say that antibiotics and antibacterial agents have revolutionized health care during the last century. These compounds are, respectively, natural product and synthetic small molecules that inhibit bacterial growth. For simplicity, in this review, the term antibiotic will be used to refer to both natural products and synthetic molecules. 

Derivatives of all three heterocyclic systems have been widely investigated for use in synthetic drugs (see also above) amongst the most commonly used compounds are the antibacterial Trimethoprim, the antimalarial Pyrimethamine and the anti-hypertensive agent Hydralazine (containing a phthalazine nucleus). Piperazine (hexahydropyrazine) is used in the treatment of intestinal nematode (worm) infections. 

Uses Antibacterial, preservative, wetting agent, solubilizer in cosmetics, emulsions, cough syrups, lozenges, topical sol ns. antimicrobial, antistat, deodorant agent, emulsifier, surfactant in cosmetics topical anti-infective antiseptic in pharmaceuticals Use Level 0.1%... 

Uses ophthalmic preservative topical anti-infective topical veterinary antibacterial and antifungal agent bacteriostat fimgistat preservative in vaccines, antitoxins, skin-testing allergens, antiseptics, contact-lens solutions, and cosmetic products like eye makeup A... 

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