Anti-infective drugs

List some nursing diagnoses particular to a patient taking the anti-infective drugs presented in this chapter. 

Unit II contains 11 chapters that present the anti-infective drugs, grouped according to classification. These shorter chapters allow for more inclusive coverage of the different types of anti-infectives and the appropriate nursing considerations for each classification. 

Shim JH, Hong Z, Wu JZ (2006) Recent patents on nucleoside and nucleotide inhibitors for HCV, Recent Patents Anti-Infect Drug Disc 1 323-331... 

H. C. Maltezou, Recent Patents on Anti Infect. Drug Discov., 2008, 3,192. 

DuPont HL, Copperstock M, Corrado ML, Fe-kety R, Murray DM Evaluation of new anti-infective drugs for the treatment of acute infectious diarrhea. Clin Infect Dis 1992 15(suppl 1) S228-S235. 

The study by Prentis et al. [4] included an analysis of 198 NCEs, developed between 1964 and 1985 by British pharmaceutical companies but had not been marketed for reasons presented in Figure 1.1. Kennedy [5] further analyzed these data and noticed that a high number of anti-infective drug development projects were all terminated... 

Mulvey, G., Kitov, P. 1., Marcato, P., Bundle, D. R., and Armstrong, G. D. (2001). Glycan mimicry as a basis for novel anti-infective drugs. Biochimie 83, 841-847. 

J. Finn J. Tao, Aminoacyl-tRNA Synthetases as Anti-infective Drug Targets. In The Aminoacyi-tRNA Synthetases] M. Ibba,... 

Melo MN, Dugourd D, Castanho MARB. (2006) Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides. Recent Pat Anti-Infect Drug Discov 1 201-207. 

Hudson AT. (1993) Atovaquone — a novel broad-spectrum anti-infective drug. Parasitol Today 9 66-68. 

Over the past 45 or so years one of the most fascinating stories in clinical pharmacology has gradually unravelled. In the 1930s it had been recognized that many of the original anti-infective drugs, the... 

Both of these elements are causing nervousness amongst regulators. So much so that, for example, the FDA Anti-Infective Drugs Advisory Committee (AIDAC) have recently recommended that the non-inferiority design should no longer... 

FDA (1992) Points to Consider on Clinical Development and Labeling of Anti-Infective Drug Products ... 

AIDAC Anti-Infective Drugs Advisory Committee... 

Soreth, Janice, M.D., Acting Director, Division of Anti-Infective Drug Products, ODE IV CDER, March 25, 2001. 

B) ACTION BY THE PEDIATRIC ADVISORY SUBCOMMITTEE OF THE ANTI-INFECTIVE DRUGS ADVISORY COMMITTEE. Not later than 90 days after receiving a referral under subparagraph (A)(ii), the Pediatric Advisory Committee shall... 

Clearly, identification of resistance mechanisms and of potential intracellular targets all lead to information which would be very useful for the development of novel anti-infective drugs by peptide-based design, once the structure of these targets is known. In addition, identification of transport proteins that may... 

Bacterial membranes have a much more complex construction than mammalian membranes. This enables bacteria to survive in the various environments of host organisms. Knowledge of the composition and functioning of bacterial membranes is therefore essential to the development of anti-infective drugs. In order to be effective, antibacterial agents not only have to have optimal pharmacokinetic properties such as uptake and distribution in the patient, but they must also be able to cross an additional barrier, the cell wall of the bacteria, so that they can reach the target site. This additional barrier is remarkable on account of its rigidity and permeability. The construction and structural uniqueness of this barrier is briefly described below. 

---